Trans-arterial chemoembolization (TACE) in patients with unresectable Hepatocellular carcinoma: Experience from a tertiary care centre in India

Shashi Bala Paul; Shivanand Gamanagatti; Vishnubhatla Sreenivas; Sheragaru Hanumanthappa Chandrashekhara; Amar Mukund; Manpreet Singh Gulati; Arun Kumar Gupta; Subrat Kumar Acharya

doi:10.4103/0971-3026.82294

Indian Journal of Radiology and Imaging, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2011; 21(02): 113-120
DOI: 10.4103/0971-3026.82294

Interventional Radiology

Trans-arterial chemoembolization (TACE) in patients with unresectable Hepatocellular carcinoma: Experience from a tertiary care centre in India

Shashi Bala Paul

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

,

Shivanand Gamanagatti

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

,

Vishnubhatla Sreenivas

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

,

Sheragaru Hanumanthappa Chandrashekhara

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

,

Amar Mukund

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

,

Manpreet Singh Gulati

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

,

Arun Kumar Gupta

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

,

Subrat Kumar Acharya

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India

› Institutsangaben

Abstract

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Abstract

Aims: To evaluate the outcome following transarterial chemoembolization (TACE) and to identify the predictors of survival in patients with unresectable hepatocellular carcinoma (HCC). Material and Methods: HCC patients reporting to our hospital (2001-2007) were subjected to clinical, biochemical, and radiological examination. TACE was performed in those who fulfilled the inclusion criteria. Follow-up assessment was done with multiphase CT scan of the liver at 1, 3, and 6 months. Tumor response and survival rate were estimated. Univariate and multivariate analyses were done for determinants of survival. Results: A total of 73 patients (69 males, 4 females; mean age 49±13.4 years) were subjected to 123 sessions of TACE. The Child′s classification was: A - 56 patients and B - 17 patients. Barcelona Clinic staging was: A - 20 patients, B - 38 patients, and C - 15 patients. Tumor size was ≤5cm in 28 (38%) patients, >5-10 cm in 28 (38%) patients, and >10 cm in 17 (23%) patients. Median follow-up was for 12 months (range: 1-77 months). No significant postprocedure complications were encountered. Overall survival rate was 66%, 47%, and 36.4% at 1, 2, and 3 years, respectively. Tumor size emerged as an important predictor of survival. Conclusion: TACE offers a reasonable palliative therapy for HCC. Initial tumor size is an independent predictor of survival.

Keywords

Hepatocellular carcinoma - survival rate - transarterial chemoembolisation

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Referenzen

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