Abstract
Background: Treatment of acute leukemia′s- a common childhood malignancy, involves intensive
and powerful multi-drug chemotherapeutic regime. Oral lesions are a common complication
in these patients affecting oral health status. Aim: This study was conducted to evaluate and assess the oral health status of newly diagnosed
leukemic pediatric patients during induction phase and its correlation to outcome
of induction therapy. Material Methods: Oral examinations was done in 33 children between the age group of 5-15 years with
acute lymphoblastic leukemia (ALL) and acute myloblastic leukemia (AML), who were
undergoing chemotherapy. Oral Hygiene Index- Simplified, (OHI-S) decayed missing filled
teeth index (def/DMFT), Loe and Sillness index for gingiva, and complete blood count
at first and fourth week of induction phase were recorded for each patient. The changes
in the oral health status were analyzed with Wilcoxon signed rank test. Results: During an induction phase it was observed that level of OHI-S (P = 0.002), Loe and Sillness index (P = 0.003), def/DMFT index (P = 0.076), platelet count (P = 0.00) increased significantly and no significant difference was noted in hemoglobin
(P = 0.4) and total leucocytes count (P = 0.11). Conclusion: It was observed that, although oral health status had significantly worsened, the
induction outcome was not affected.
Keywords
Induction phase - leukemia - oral hygiene - oral lesions
