Interference of apoptosis in the pathophysiology of subarachnoid hemorrhage

C Palade; Alexandru Ciurea; D Nica; R Savu; Horatiu Moisa

doi:10.4103/1793-5482.116389

Asian Journal of Neurosurgery, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Asian J Neurosurg 2013; 8(02): 106-111
DOI: 10.4103/1793-5482.116389

REVIEW ARTICLE

Interference of apoptosis in the pathophysiology of subarachnoid hemorrhage

C Palade

Department of Neurosurgical, Carol Davila University School of Medicine, The National Center for Excellency in Neurosurgery, Bagdasar-Arseni Emergency Hospital, Bucharest

,

Alexandru Ciurea

Department of Neurosurgical, Carol Davila University School of Medicine, The National Center for Excellency in Neurosurgery, Bagdasar-Arseni Emergency Hospital, Bucharest

,

D Nica

¹Department of Neurosurgical, Sf. Pantelimon Emergency Hospital, Bucharest

,

R Savu

²Department of Neurosurgical, Euromedica Hospital, Baia Mare

,

Horatiu Moisa

Department of Neurosurgical, Carol Davila University School of Medicine, The National Center for Excellency in Neurosurgery, Bagdasar-Arseni Emergency Hospital, Bucharest

› Institutsangaben

Abstract

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Programmed cell death is crucial for the correct development of the organism and the clearance of harmful cells like tumor cells or autoreactive immune cells. Apoptosis is initiated by the activation of cell death receptors and in most cases it is associated with the activation of the cysteine proteases, which lead to apoptotic cell death. Cells shrink, chromatin clumps and forms a large, sharply demarcated, crescent-shaped or round mass; the nucleus condenses, apoptotic bodies are formed and eventually dead cells are engulfed by a neighboring cell or cleared by phagocytosis. The authors have summarized the most important data concerning apoptosis in subarachnoid hemorrhage that have been issued in the medical literature in the last 20 years.

Key-words:

Apoptosis - cell death receptors - programmed cell death - subarachnoid hemorrhage

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