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CC BY-NC-ND 4.0 · Asian J Neurosurg 2018; 13(01): 98-101
DOI: 10.4103/1793-5482.185057
Case Report

Isolated extracranial intraosseous metastasis of an intracranial meningioma following bevacizumab therapy: Case report and review of the literature

Debraj Mukherjee
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048
,
Jethro Hu
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048
,
Ray Chu
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Meningiomas account for a significant proportion of all primary intracranial tumors; distant metastasis is quite rare. We report a patient with resected, atypical meningioma. The patient's clinical course over 5 years included two craniotomies, a course of radiation, and a shortened course of bevacizumab. Only 5 months after starting bevacizumab, the patient developed an isolated left clavicular pathological fracture attributable to metastatic anaplastic meningioma. This constitutes the first report of meningioma with isolated extracranial intraosseous metastasis in the modern English literature and highlights concerns associated with the use of anti-angiogenic agents in promoting more invasive tumor phenotypes upon disease recurrence.

Key-words:

Anaplastic meningioma - atypical meningioma - bevacizumab - extracranial intraosseous metastasis


Publication History

Article published online:
14 September 2022

© 2018. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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