Spielt das Herz noch mit? Labordiagnostik bei Herzerkrankungen – mehr als nur Troponin und BNP

Die kardiologische Diagnostik ist schon lange Domäne bildgebender Verfahren: Vor allem Ultraschall, aber auch Röntgen und EKG haben ihren festen Platz in der diagnostischen Aufarbeitung „herzauffälliger“ Patienten. Ist in diesem Bereich der Tiermedizin noch Bedarf bzw. Platz für labordiagnostische Untersuchungen? Die Antwort auf diese Frage ist ein klares „Ja“!

• Literatur

• 1 Gavazza A, Fruganti A, Turinelli V. et al. Canine Traditional Laboratory Tests and Cardiac Biomarkers. Front Vet Sci 2020; 7: 320
• 2 Baisan RA, De Rosa A, Di Loria A. et al. Cardiac biomarkers in clinical practice of dog and cat – a review. HVM Bioflux 2016; 8: 50-58
• 3 Wesselowski S, Lidbury J, Saunders AB. et al. Analytical validation, sample stability, and clinical evaluation of a new high-sensitivity cardiac troponin I immunoassay for use in dogs, with comparison to a previous ultrasensitive assay. PLoS One 2023; 18: e0288801
• 4 Langhorn R, Oyama MA, King LG. et al. Prognostic importance of myocardial injury in critically ill dogs with systemic inflammation. J Vet Intern Med 2013; 27: 895-903
• 5 Langhorn R, Thawley V, Oyama MA. et al. Prediction of long-term outcome by measurement of serum concentration of cardiac troponins in critically ill dogs with systemic inflammation. J Vet Intern Med 2014; 28: 1492-1497
• 6 Polizopoulou ZS, Koutinas CK, Dasopoulou A. et al. Serial analysis of serum cardiac troponin I changes and correlation with clinical findings in 46 dogs with mitral valve disease. Vet Clin Pathol 2014; 43: 218-225
• 7 Hori Y, Iguchi M, Heishima Y. et al. Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy. J Vet Intern Med 2018; 32: 922-929
• 8 Lobetti R, Dvir E, Pearson J. Cardiac troponins in canine babesiosis. J Vet Intern Med 2002; 16: 63-68
• 9 Diniz PP, de Morais HS, Breitschwerdt EB. et al. Serum cardiac troponin I concentration in dogs with ehrlichiosis. J Vet Intern Med 2008; 22: 1136-1143
• 10 Silvestrini P, Piviani M, Alberola J. et al. Serum cardiac troponin I concentrations in dogs with leishmaniasis: correlation with age and clinicopathologic abnormalities. Vet Clin Pathol 2012; 41: 568-574
• 11 Bartnicki M, Łyp P, Dębiak P. et al. Cardiac disorders in dogs infected with Babesia canis. Pol J Vet Sci 2017; 20: 573-581
• 12 Hagman R, Lagerstedt AS, Fransson BA. et al. Cardiac troponin I levels in canine pyometra. Acta Vet Scand 2007; 49: 6
• 13 Liu M, Köster LS, Fosgate GT. et al. Cardiovascular-renal axis disorder and acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy. J Vet Intern Med 2020; 34: 1078-1090
• 14 Kilkenny E, Watson C, Dukes-McEwan J. et al. Evaluation of serum cardiac troponin-I concentrations for diagnosis of infective endocarditis in dogs. J Vet Intern Med 2021; 35: 2094-2101
• 15 Hamacher L, Dörfelt R, Müller M. et al. Serum cardiac troponin I concentrations in dogs with systemic inflammatory response syndrome. J Vet Intern Med 2015; 29: 164-170
• 16 Nobre Pacífico Pereira KH, Hibaru VY, Fuchs KDM. et al. Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs. Theriogenology 2022; 180: 146-153
• 17 Zaldívar-López S, Marín LM, Iazbik MC. et al. Clinical pathology of Greyhounds and other sighthounds. Vet Clin Pathol 2011; 40: 414-425
• 18 Couto KM, Iazbik MC, Marín LM. et al. Plasma N-terminal pro-B-type natriuretic peptide concentration in healthy retired racing Greyhounds. Vet Clin Pathol 2015; 44: 405-409
• 19 Okamoto R, Ali Y, Hashizume R. et al. BNP as a Major Player in the Heart-Kidney Connection. Int J Mol Sci 2019; 20: 3581
• 20 de Lima GV, Ferreira FDS. N-terminal-pro brain natriuretic peptides in dogs and cats: A technical and clinical review. Vet World 2017; 10: 1072-1082
• 21 Brložnik M, Pečjak A, Nemec Svete A. et al. Selected hematological, biochemical, and echocardiographic variables as predictors of survival in canine patients with myxomatous mitral valve disease and congestive heart failure. J Vet Cardiol 2023; 46: 18-29
• 22 Baumwart RD, Meurs KM. Assessment of plasma brain natriuretic peptide concentration in Boxers with arrhythmogenic right ventricular cardiomyopathy. Am J Vet Res 2005; 66: 2086-2089
• 23 Fredericks S, Merton GK, Lerena MJ. et al. Cardiac troponins and creatine kinase content of striated muscle in common laboratory animals. Clin Chim Acta 2001; 304: 65-74
• 24 Cridge H, Langlois DK, Steiner JM. et al. Cardiovascular abnormalities in dogs with acute pancreatitis. J Vet Intern Med 2023; 37: 28-36