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Thromb Haemost 1961; 05(02): 149-161
DOI: 10.1055/s-0038-1654916
Originalarbeiten – Original Article – Travaux Originaux
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A Comparison of the Fibrinolytic and Fibrinogenolytic Effects of Plasminogen Activators and Proteolytic Enzymes in Plasma[*]

William D. Sawyer
1   Department of Medicine, Washington University School of Medicine, St. Louis, Mo
,
Norma Alkjaersig
1   Department of Medicine, Washington University School of Medicine, St. Louis, Mo
,
Anthony P. Fletcher
1   Department of Medicine, Washington University School of Medicine, St. Louis, Mo
,
Sol Sherry
1   Department of Medicine, Washington University School of Medicine, St. Louis, Mo
› Author Affiliations
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Publication History

Publication Date:
21 June 2018 (online)

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Summary

1. A sensitive test system has been described whereby the respective fibrinolytic and fibrinogenolytic effects of plasminogen activators and proteolytic enzymes in plasma may be quantitated separately by use of isotopically labeled substrates.

2. Plasminogen activators in the plasma-clot system were demonstrated to lyse more fibrin per unit fibrinogen lysed than either plasmin or trypsin. No evidence was obtained to suggest the formation of a plasmin-antiplasmin complex with special “fibrinolytic” porperties.

3. Comparison of the effects of streptokinase and urokinase in plasma revealed discrete differences in the ratio of their fibrinolytic-fibrinogenolytic activities.

* This work was supported by grants-in-aid from the National Heart Institute (H 3745), Bethesda, Md.; Lederle Laboratories Division, American Cyanamid Co., Pearl River, N. Y.; and Abbott Laboratories, Chicago, Ill.


 

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