Bisxanthones from Hypericum japonicum: Inhibitors of PAF-Induced Hypotension[*]

Abstract

The CHCl₃-soluble part (HJ) of the MeOH extract from Hypericum japonicum afforded new bisxanthones, jacarelhyperols A (1) and B (2). The structures were elucidated by spectral methods. These compounds and HJ showed significant inhibitory effects against PAF-induced hypotension by an in vivo evaluation method, which can reveal the pharmacological action of the test material.

Abbreviations

PAF:platelet-activating factor

HEL:hen egg-white lysozyme

CV 3988:rac-3-(N-n-octadecyl carbamoyloxy)-2-methoxypropyl2-thiazoliethyl phosphate

Key words

Hypericum japonicum Thunb. - Clusiaceae - PAF antagonist - bisxanthones - jacarelhyperols A and B

1 * Part 10 in the series; for part 9 see ref. [3].

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1 * Part 10 in the series; for part 9 see ref. [3].