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Pharmacopsychiatry 2002; 35(4): 155-156
DOI: 10.1055/s-2002-33198
Case Report
© Georg Thieme Verlag Stuttgart · New York

Meige Syndrome with Apraxia of Lid Opening after the Discontinuation of Sulpiride Treatment

S. Tsuji1 , S. Kikkawa1 , J. Horiguchi2 , H. Yamashita1 , A. Kagaya1 , S. Morinobu1 , S. Yamawaki1
  • 1Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima, Japan
  • 2Department of Psychiatry. Shimane Medical University, Shimane, Japan
Further Information

Publication History

Manuscript received: 4. 4. 2001 Revised: 31. 10. 2001

Accepted: 20. 12. 2001

Publication Date:
06 August 2002 (online)

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We report a case of Meige syndrome with apraxia of lid opening that lasted for about seven months after discontinuation of sulpiride treatment. To our knowledge, this is the first report demonstrating that Meige syndrome with apraxia of lid opening is induced by sulpiride, and that the condition persists.

References

  • 1 Ananth J, Edelmuth E, Dargan B. Meige’s syndrome associated with neuroleptic treatment.  Am J Psychiatry. 1988;  145 513-515
    PubMedGoogle Scholar
  • 2 Boghen D. Apraxia of lid opening: a review.  Neurology. 1997;  48 1491-1494
    PubMedGoogle Scholar
  • 3 Casey D E. Pharmacology of blepharospasm-oromandibular dystonia syndrome.  Neurology. 1980;  30 690-695
    PubMedGoogle Scholar
  • 4 Farde L, Nordstrom A L. PET analysis indicates atypical central dopamine receptor occupancy in clozapine-treated patients.  Br J Psychiatry Suppl. 1992;  17 30-33
    PubMedGoogle Scholar
  • 5 Hayashi T, Furutani M, Taniyama J, Kiyasu M, Hikasa S, Horiguchi J J. et al . et alNeuroleptic-induced Meige’s syndrome following akathisia: pharmacologic characteristics.  Psychiatry Clin Neurosci. 1998;  52 445-448
    CrossrefPubMedGoogle Scholar
  • 6 Kebabian J W, Calne D B. Multiple receptors for dopamine.  Nature. 1979;  277 93-96
    PubMedGoogle Scholar
  • 7 Meige H. Les convulsions de la face, une forme clinique de convulsion faciale, bilaterale et médiane.  Revue Neurologique. 1910;  20 437-443
    PubMedGoogle Scholar
  • 8 Miller L G, Jankovic J. Sulpiride-induced tardive dystonia.  Mov Disord. 1990;  5 83-84
    CrossrefPubMedGoogle Scholar
  • 9 Moore S, Kenyon P. Atypical antipsychotics, clozapine and sulpiride do not antagonise amphetamine-induced stereotyped locomotion.  Psychopharmacology (Bed). 1994;  114 123-130
    PubMedGoogle Scholar
  • 10 Seeman P, Corbett R, Van Tol H H. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.  Neuropsychopharmacology. 1997;  16 93-110; discussion 1 - 35
    CrossrefPubMedGoogle Scholar
  • 11 Stahl S M. Conventional Neuroleptic Drugs for Schizophrenia and Novel Antipsychotic Agents.  Essential Psychopharmacology. United Kingdom; CAMBRIDGE UNIVERSITY PRESS 1996: p.270
    Google Scholar
  • 12 Stahl S M, Yesavage J A, Berger P A. Pharmacologic characteristics of Meige dystonia: differentiation from tardive dyskinesia.  J Clin Psychiatry. 1982;  43 445-446
    PubMedGoogle Scholar
  • 13 Tamminga C A, Gerlach J. New neuroleptics and experimental antipsychotics in schizophrenia. in Psychopharmacology, The third generation of progress. ed. by Meltzer HY New York; Raven Press 1987: p. 1129-1140
    Google Scholar
  • 14 Tanner C M, Glantz R H, Klawans H L. Meige disease: acute and chronic cholinergic effects.  Neurology. 1982;  32 783-785
    PubMedGoogle Scholar
  • 15 Tolosa E S, Lai C. Meige disease: striatal dopaminergic preponderance.  Neurology. 1979;  29 1126-1130
    PubMedGoogle Scholar
  • 16 Weiner W J, Nausieda P A, Glantz R H. Meige syndrome (blepharospasm-oromandibular dystonia) after long-term neuroleptic therapy.  Neurology. 1981;  31 1555-1556
    PubMedGoogle Scholar

Shigeto Yamawaki,MD, PhD 

Department of Psychiatry and Neurosciences

Hiroshima University School of Medicine

1-2-3 Kasumi, Minami-ku

Hiroshima 734-8551

Japan

Phone: +81 (82) 257-5207

Fax: +81 (82) 257-5209