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Planta Med 2002; 68(9): 790-793
DOI: 10.1055/s-2002-34412
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Quinoline Alkaloids and Anti-Platelet Aggregation Constituents from the Leaves of Melicope semecarpifolia

Jih-Jung Chen1 , Ya-Ling Chang2 , Che-Ming Teng2 , Chao-Chen Su1 , Ih-Sheng Chen3
  • 1Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
  • 2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
  • 3Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
Further Information

Publication History

Received: January 4, 2002

Accepted: April 21, 2002

Publication Date:
30 September 2002 (online)

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Abstract

Three new quinoline alkaloids, melisemine, confusadine, and melicarpinone, together with twelve known compounds have been isolated from the leaves of Melicope semecarpifolia. The structures of these three compounds were determined through spectral analyses. Confusadine was demonstrated to be an anti-platelet aggregation constituent.

Key words

Melicope semecarpifolia - Rutaceae - leaves - alkaloids - quinoline - 2-quinolone - melisemine - furoquinolines - confusadine - melicarpinone - anti-platelet aggregation activity

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Prof. Dr. I. S. Chen

Graduate Institute of Pharmaceutical Sciences

Kaohsiung Medical University

Kaohsiung, Taiwan

Republic of China

Email: m635013@cc.kmu.edu.tw

Fax: +886-7-3210683