Planta Med 2004; 70(10): 883-886
DOI: 10.1055/s-2004-832610
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Prenylated Indole Alkaloids from Flustra foliacea with Subtype Specific Binding on NAChRs

Lars Peters1 , Anthony D. Wright1 , Stefan Kehraus1 , Daniela Gündisch2 , M. C. Tilotta2 , Gabriele M. König1
  • 1Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany
  • 2Institute for Pharmaceutical Chemistry, University of Bonn, 53115 Bonn, Germany
Further Information

Publication History

Received: February 23, 2004

Accepted: July 26, 2004

Publication Date:
18 October 2004 (online)

Abstract

Several brominated indole alkaloids and a diterpene (1 - 7) were isolated from the dichloromethane extract of the North Sea Bryozoan Flustra foliacea. Alkaloid 4 is a new natural product, whose structure was elucidated by interpretation of spectroscopic data (NMR, mass, UV, and IR). All compounds were tested for their in vitro affinity towards the α4ß2* and α7* subtype of the neuronal nicotinic acetylcholine receptor (nAChR) using radioligand binding assays. Deformylflustrabromine (3) and deformylflustrabromine B (4) were shown to have affinities in the lower micromolar range for nAChRs, differing in their subtype preference.

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Prof. Dr. Gabriele M. König

Institute for Pharmaceutical Biology

University of Bonn

Nußallee 6

53115 Bonn

Germany

Phone: +49 228 733747

Fax: +49 228 733250

Email: g.koenig@uni-bonn.de

URL: http://www.uni-bonn.de/pharmbio/queen/GAWK.html