The Effect of Additives on TEMPO-Mediated Alkoxyamine Isomerizations: Experiments and Simulations

Abstract

Thermal radical alkoxyamine isomerizations controlled by the persistent radical effect are investigated. These processes can be accelerated upon addition of substoichiometric amounts of Lewis acids, Brønsted acids and various reducing reagents. The experimental findings are further supported by simulations.

radical chemistry - synthetic methods - nitroxides - simulations - persistent radicals

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