Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events

Bernhard Richter; Alexander Niessner; Martina Penka; Marija Grdić; Sabine Steiner; Barbara Strasser; Sophie Ziegler; Gerlinde Zorn; Gerald Maurer; Vera Simeon-Rudolf; Johann Wojta; Kurt Huber

doi:10.1160/TH05-03-0158

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2005; 94(06): 1306-1311
DOI: 10.1160/TH05-03-0158

Cell Signalling and Vessel Remodelling

Schattauer GmbH

Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events

Bernhard Richter^*

¹Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria

,

Alexander Niessner^*

¹Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria

,

Martina Penka

²Department of Cardiology and Emergency Medicine, Wilhelminen-Hospital, Vienna, Austria

,

Marija Grdić

³Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

,

Sabine Steiner

⁴Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Austria

,

Barbara Strasser

⁵Department of Internal Medicine IV, Division of Sports Medicine, Medical University of Vienna, Austria

,

Sophie Ziegler

⁴Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Austria

,

Gerlinde Zorn

¹Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria

,

Gerald Maurer

¹Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria

,

Vera Simeon-Rudolf

⁶Institute for Medical Research and Occupational Health, Zagreb, Croatia

,

Johann Wojta

¹Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria

,

Kurt Huber

¹Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria

²Department of Cardiology and Emergency Medicine, Wilhelminen-Hospital, Vienna, Austria

› Institutsangaben

Abstract

Summary

Asymmetric dimethylarginine (ADMA), myeloperoxidase (MPO) and paraoxonase 1 (PON1) are directly involved in the pathogenesis of atherosclerosis by modulation of oxidative stress and/or NO bioavailability. We aimed to assess whether endurance exercise which is known to be cardioprotective could beneficially affect these novel risk markers. Thirty-two subjects (31–68 yrs, 56% males) with elevated cardiovascular risk including ten patients with coronary artery disease volunteered for a supervised 12-week endurance training (196 ± 15 min/week).Their fitness evaluated by 2 km test runs improved significantly after training (pre: 17.3±0.8 vs. post: 15.7±0.9min, p<0.001). ADMA (pre: 0.94±0.03 vs. post: 0.75±0.04 μmol l⁻¹) and MPO (pre:296.8±22.2 vs.post:185.7±19.5 ng ml⁻¹) serum levels decreased significantly by 17.6±4.6% and 28.5±7.5%, respectively, after training (both p<0.001).Their down-regulation was inversely correlated (ADMA: r=-0.609, p<0.001, MPO: r=-0.437, p=0.014) with the up-regulation of plasma cGMP levels (Cyclic-guanosine 3`,5`-monophosphate; pre: 1.6±0.12 vs. post: 2.21±0.2 μmol ml⁻¹, p=0.001) reflecting NO production. PON1 activity towards phenylacetate was not significantly influenced by training (pre: 133±6 vs. post: 130±5 μmol ml⁻¹ min⁻¹, p=0.375). In a matched inactive control group (n=16) ADMA, MPO, cGMP levels and PON1 activity did not change over time. ADMA, MPO and cGMP changes were significantly different between participants and controls (all p<0.05). Regular endurance exercise was successful in reducing the circulating levels of two promising cardiovascular risk markers, ADMA and MPO, in persons prone to cardiac events. These changes may result in numerous antiatherosclerotic effects such as improvement of NO bioavailability, reduction of oxidative stress and lipid peroxidation.

Keywords

Exercise - atherosclerosis - asymmetric dimethylarginine - myeloperoxidase - paraoxonase 1

Volltext

Referenzen

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