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Exp Clin Endocrinol Diabetes 1988; 91(3): 327-333
DOI: 10.1055/s-0029-1210765
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Molecular Interaction of Non-Steroidal Compounds with Uterine Progesterone Receptor (Part II)1)

Anila Agnihotri,  Neelima, M. Seth, A. P. Bhaduri, A. K. Srivastava, V. P. Kamboj
  • Division of Endocrinology (Head: Dr. V. P. Kamboj), Central Drug Research Institute, (Director: Dr. M. M. DHAR), Lucknow, India
1) CDRI Communication No. 3604.
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Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

Some possible non-steroidal antiprogestins were evaluated for their receptor binding activity by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of the 42 compounds belonging to 5 different series tested, dimethyl ester of monobenzylidene succinic acid, 4-ethoxycarbonyl-3-(m-methoxybenzyl)-5-(m-anisyl)-γ-butyrolactone and 2-(3-benzyl-oxybenzyl)-3-(3-acetoxybenzyl)butane-1,4-diol exhibit around 20% inhibition of 3H-progesterone binding to uterine cytosol in both species.

Key words

Human - Rabbit - Progesterone - Receptor - Inhibition