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Synfacts 2011(5): 0518-0518
DOI: 10.1055/s-0030-1259824
DOI: 10.1055/s-0030-1259824
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Fluorination of Enynes
H. Peng, G. Liu*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
15 April 2011 (online)
Significance
The construction of carbon-fluorine bonds is an important yet difficult task in the synthesis of pharmaceuticals. Based on previous results on aminofluorination of styrenes (J. Am. Chem. Soc. 2010, 132, 2856), the authors present a palladium-catalyzed tandem fluorination and cyclization of enynes to give vinyl fluorides.