The PREMIER Study. A Multicenter, Randomized, Double-Blind Clinical Trial of Combination Therapy With Adalimumab Plus Methotrexate Versus Methotrexate Alone or Adalimumab Alone in Patients With Early, Aggressive Rheumatoid Arthritis Who Had Not Had Previous Methotrexate Treatment. - Breedveld,FC.; Weisman,MH.; Kavanaugh,AF. (Arthritis Rheum, 2006)