Disruption of the internal thioester bond in the third component of complement (C3) results in the exposure of neodeterminants also present on activation products of C3 - Hack, C E; Paardekooper, J; Smeenk, R J T; Abbink, J J; Eerenberg, A J M; Nuijens, J H (An analysis with monoclonal antibodies. J Immunol, 1988)