TY - JOUR AU - Güney, Kırdar; Tatar, Sedat; Özel, Bora; Seymen, Cemile; Elmas, Çiğdem; Tuncer, Serhan; Çenetoğlu, Seyhan TI - The Effect of Minocycline on Fat Graft Survival and Apoptotic Pathway SN - 0736-6825 SN - 1098-8793 PY - 2019 JO - Facial Plast Surg JF - Facial Plastic Surgery LA - EN VL - 35 IS - 01 SP - 096 EP - 102 ET - 2019/01/17 DA - 2019/02/13 KW - fat grafting KW - adipocyte KW - adipose tissue KW - apoptosis KW - minocycline AB - Variable absorption rate is one of the biggest problems of fat grafting and one of the most important causes of fat graft volume loss is apoptosis. Minocycline is a tetracycline derivative and besides its antibacterial capacity, it has been widely using for anti-apoptotic effects. This study was designed to investigate the effect of minocycline on fat graft survival and adipocyte apoptosis. A total of two main and eight subgroups were designed and a total of 48 experimental animals, 6 in each group, were used. Fat grafts are obtained from Wistar albino rats and implanted to dorsal area of rats. Local and systemic minocycline was applied in the study groups. On the 9th day, apoptotic cells were detected by the terminal deoxynucleotidyl transferase dUTP nick end labeling method and on the 90th day morphologic characteristics and viability of adipocytes were evaluated using histologic and immunohistochemical methods and statistically compared. This study revealed that the fat grafts were bigger, and they kept their structures better and they were more vascular in the minocycline groups and apoptosis was significantly lower in the minocycline groups. The authors demonstrated that minocycline increases fat graft survival and statistical improvement in apoptosis inhibition via using minocycline therapy has been shown. PB - Thieme Medical Publishers DO - 10.1055/s-0039-1677709 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1677709 ER -