Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth. - Blakesley,V.A.; Koval,A.P.; Stannard,B.S.; Scrimgeour,A.; LeRoith,D. (J Biol Chem, 1998)