Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. - Goodyear,L.J.; Giorgino,F.; Sherman,L.A.; Carey,J.; Smith,R.J.; Dohm,G.L. (J Clin Invest, 1995)