Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps- Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells - Nguyen, DH (J Biol Chem, 2000)
et al.