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Semin Liver Dis 2023; 43(02): 234-244
DOI: 10.1055/a-2097-0660
Review Article

HNF4α in Hepatocyte Health and Disease

Manasi Kotulkar
1   Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas
,
Dakota R. Robarts
1   Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas
,
Udayan Apte
1   Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas
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Abstract

Hepatocyte nuclear factor 4 α (HNF4α) is a highly conserved member of the nuclear receptor superfamily expressed at high levels in the liver, kidney, pancreas, and gut. In the liver, HNF4α is exclusively expressed in hepatocytes, where it is indispensable for embryonic and postnatal liver development and for normal liver function in adults. It is considered a master regulator of hepatic differentiation because it regulates a significant number of genes involved in hepatocyte-specific functions. Loss of HNF4α expression and function is associated with the progression of chronic liver disease. Further, HNF4α is a target of chemical-induced liver injury. In this review, we discuss the role of HNF4α in liver pathophysiology and highlight its potential use as a therapeutic target for liver diseases.

Keywords

hepatocyte nuclear factor 4 α - liver development - hepatocyte differentiation - therapeutic target


Publication History

Accepted Manuscript online:
22 May 2023

Article published online:
05 July 2023

© 2023. Thieme. All rights reserved.

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