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Planta Med 2024; 90(01): 38-46
DOI: 10.1055/a-2186-3260
Biological and Pharmacological Activity
Original Papers

New Lupanes from Alstonia scholaris Reducing Uric Acid Level

Bin-Yuan Hu‡
1   Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
,
Yun-Li Zhao‡
1   Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
,
Yuan Xu
1   Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
,
Xiao-Na Wang
1   Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
,
Xiao-Dong Luo
1   Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
2   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
› InstitutsangabenGefördert durch: Yunnan Characteristic Plant Screening and R&D Service CXO Platform 2022YKZY001
Gefördert durch: Scientific and Technological Innovation Team of Yunnan Province 202105AE160006
Gefördert durch: High-level Talent Promotion and Training Project of Kunming 2022SCP003
› Weitere Informationen
    Lizenzen und Reprints

Abstract

Twelve lupanes including three new compounds named alstoscholarilups A−C (1–3) were isolated from the leaves of Alstonia scholaris. Their structures were elucidated by spectroscopic analysis and ECD calculation. Structurally, compound 1 with a rare A ring-seco skeleton formed lactone and degraded C-3, while 2 with a 28-nor and 3 with a 29-nor-lupane skeleton supported the phytochemical diversity and novelty of the plant. Pharmacologically, compounds 4, 7, and 10 reduced the serum uric acid (UA) levels of mice significantly.

Key words

Alstonia scholaris - Apocynaceae - reducing UA levels - lupanes

Supporting Information

    Computational data of compounds 1–3; NMR, HRESIMS, ORD, CD, and IR of compounds 1–5; the physical and spectroscopic data of the known compounds are available as Supporting Information.

  • Ergänzendes Material


Publikationsverlauf

Eingereicht: 19. Juni 2023

Angenommen nach Revision: 28. September 2023

Artikel online veröffentlicht:
19. Oktober 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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