Three New Vanilloid Derivatives from the Stems of Baccaurea ramiflora

Abstract

Three new (1−3) and four known (4−7) compounds were isolated from the stems of Baccaurea ramiflora. By analysis of 1D, 2D NMR, and MS data, the new compounds were identified as 4′-O-(6-O-vanilloyl)-β-D-glucopyranosyl tachioside D (1), 6′-O-vanilloylpicraquassioside D (2), and 6′-O-vanilloylicariside B₅ (3). Compound 1 exhibited significant DPPH radical-scavenging activity, with an IC₅₀ value of 36.9 µM, while compound 4 revealed weak antioxidant activity against H₂O₂-induced impairment in PC12 cells.

Key words

Baccaurea ramiflora - Euphorbiaceae - PC12 cells - antioxidant - DPPH - vanilloid

References

• 1 Lin Y F, Yi Z, Zhao Y H. Chinese Dai medicine colorful illustrations. Kunming; Yunnan Nationality Press 2003: 158-160
• 2 Yang X W, Wang J S, Ma Y L, Xiao H T, Zuo Y Q, Lin H, He H P, Li L, Hao X J. Bioactive phenols from the leaves of Baccaurea ramiflora.  Planta Med. 2007;  73 1415-1417
• 3 Miyase T, Ueno A, Takizawa N, Kobayashi H, Oguchi H. Studies on the glycosides of Epimedium grandiflorum Morr. var. thunbergianum (Miq) Nakai. III.  Chem Pharm Bull. 1988;  36 2475-2484
• 4 Champavier Y, Comte G, Vercauteren J, Allais D P, Chulia A J. Norterpenoid and sesquiterpenoid glucosides from Juniperus phoenicea and Galega officinalis.  Phytochemistry. 1999;  50 1219-1223
• 5 Yang X W, Zhao P J, Ma Y L, Xiao H T, Zuo Y Q, He H P, Li L, Hao X J. Mixed lignan-neolignans from Tarenna attenuata.  J Nat Prod. 2007;  70 521-525