Endoscopy 2021; 53(S 01): S195
DOI: 10.1055/s-0041-1724788
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Prospective Observational Study of 1L NER1006 Compared to 2L Polyethylene Glycol in Inpatients and Outpatients

T Schiefer
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
M Hollenbach
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
J Tünnemann
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
J Feisthammel
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
T Karlas
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
B Holler
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
M Heindl
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
T Bielow
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
S Beer
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
,
A Böhlig
2   University of Leipzig Medical Center, Division of Hepatology, Medical Department II, Leipzig, Germany
,
F van Bömmel
2   University of Leipzig Medical Center, Division of Hepatology, Medical Department II, Leipzig, Germany
,
A Hoffmeister
1   University of Leipzig Medical Center, Division of Gastroenterology, Medical Department II, Leipzig, Germany
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    Aims Bowel preparation for colonoscopy by polyethylene glycole (PEG) is effective but requires high-volume intake. Low-volume NER1006 was non-inferior or, at least in part, superior to PEG in prior studies. However, cleansing efficacy has not been analyzed for inpatients and outpatients specifically. Therefore, we performed a monocentric prospective observational study to address this issue.

    Methods Patients undergoing colonoscopy were included and received NER1006 (1l) or PEG (2l) in split-dose. Cleansing was analyzed using Boston Bowel Preparation Scale (BBPS). Primary endpoint was cleansing efficacy in inpatients compared to outpatients. Proportions were analyzed by means of chi-square-test or student’s t-test.

    Results Out of 598 screened individuals we could include 288 patients to the study. Main exclusion criteria were prior colon resection and emergency endoscopies. Outpatients (184) used more often NER1006 (130) compared to PEG (54) whereas inpatients (104) received mainly PEG (78) in relation to NER1006 (26). Baseline characteristics age (60.7 vs. 59.0 y, p=0.656) and gender (m: 58.3 % vs. 48.5 %, p=0.095) were comparable between NER1006 and PEG groups. Main indications for colonoscopy were surveillance and diagnostic endoscopy. Effective bowel cleansing (BBPS≥6) was comparable between NER1006 and PEG in both inpatients (NER1006: 16 of 26, PEG: 53 of 78, p=0.549) and outpatients (NER1006: 98 of 130, PEG: 40 of 54, p=0.852). In addition, acceptable overall bowel preparation quality (BBPS≥6) was not significantly different between inpatients (69 of 104) and outpatients (138 of 184, p=0.117).

    Conclusions NER1006 was non-inferior in effective bowel cleansing for colonoscopy-preparation in both inpatients and outpatients.

    Citation: Schiefer T, Hollenbach M, Tünnemann J etal. eP294 PROSPECTIVE OBSERVATIONAL STUDY OF 1L NER1006 COMPARED TO 2L POLYETHYLENE GLYCOL IN INPATIENTS AND OUTPATIENTS. Endoscopy 2021; 53: S195.


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    Publication History

    Article published online:
    19 March 2021

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