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Horm Metab Res 2004; 36(8): 550-558
DOI: 10.1055/s-2004-825796
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Effects of Soy-derived Diets on Plasma and Liver Lipids, Glucose Tolerance, and Longevity in Normal, Long-lived and Short-lived Mice

A.  Bartke1 , M.  R.  Peluso1 , N.  Moretz2 , C.  Wright1 , M.  Bonkowski1 , T.  A.  Winters1, 2 , M.  F.  Shanahan1 , J.  J.  Kopchick3 , W.  J.  Banz1, 2
  • 1Department of Physiology, Southern Illinois University School of Medicine
  • 2Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL
  • 3Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, OH, USA
Further Information

Publication History

Received 1 July 2003

Accepted after second Revision 24 January 2004

Publication Date:
24 August 2004 (online)

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Abstract

We examined the effects of diets based on a low isoflavone or a high isoflavone soy protein isolates in normal, growth-hormone receptor knockout and Ames dwarf, and Prop 1df mice that are hypoinsulinemic, insulin-sensitive, and exceptionally long-lived, as well as in growth hormone transgenic mice that are hyperinsulinemic, insulin-resistant, dyslipidemic, and short-lived. Soybean diets tended to normalize plasma cholesterol levels in dwarf and transgenic mice, while low isoflavone diet reduced plasma triglycerides in most of the examined genotypes. The effects of low isoflavone and high isoflavone diets on the levels of free and esterified cholesterol in the liver were strongly genotype-dependent. Fasting blood glucose levels were reduced and glucose tolerance improved by both low isoflavone and high isoflavone diets in growth hormone-transgenic mice and in their normal siblings. Glucose tolerance was also improved by high-isoflavone diet in growth hormone receptor knockout mice. Lifespan was increased by low isoflavone diet in normal mice from two of the examined stocks. High isoflavone diet increased lifespan in normal animals from one line, but reduced lifespan of normal mice from a different line. We conclude that dietary soy protein intake can improve plasma and hepatic lipid profiles, reduce fasting glucose, enhance capacity for glucose tolerance, and prolong life, but all of these effects are strongly genotype-dependent.

Key words

Soy diets · Lipids · Glucose · Isoflavone · GH · Longevity

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A. Bartke, Ph. D.

SIU School of Medicine, Department of Medicine, Division of Geriatric Research ·

P.O. Box 19628, Springfield, IL 62794-9628

Phone: +1 (217) 545-7962

Fax: +1 (217) 545-8006 ·

Email: abartke@siumed.edu

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