New Abietane Diterpenoids from the Mangrove Avicennia marina

Abstract

Phytochemical investigations of the twigs of Avicennia marina yielded three new abietane diterpenoids 11-hydroxy-8,11,13-abietatriene 12-O-β-xylopyranoside (1), and a pair of inseparable epimers 6Hα-11,12,16-trihydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial 11,6-hemiacetal (2) and 6Hβ-11,12,16-trihydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial 11,6-hemiacetal (3), as well as the new lignan (7′S ^∗,8′R ^∗)-4,4′,9′-trihydroxy-3,3′,5,5′-tetramethoxy-7,8-dehydro-9-al-2,7′-cyclolignan (5), together with 6,11,12,16-tetrahydroxy-5,8,11,13-abitetetraen-7-one (4), lyoniresinol (6), lyoniresinol 9′-O-β-D-glucopyranoside (7), and diacetylmartynoside (8). Structure elucidation of the new compounds was accomplished by analysis of their spectroscopic data. Compounds 2 - 4 showed moderate cytotoxic and antimicrobial activities.

Key words

Avicennia marina - Acanthaceae - abietane diterpenoids - lignans

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