Inhibition of LFA-1 Mediated T-Cell Motility by Naphthoquinones

Abstract

An in vitro T-cell migration assay has been established that can be used to study the effects of compounds on the development of T-cell polarisation with HuT-78 T lymphocytes. This assay indicates the ability of compounds tested to inhibit the inflammatory response by decreasing LFA-1-mediated T-cell motility. The effect of a series of naturally occurring quinone isolates on motility has been evaluated in this assay. Distinct differences have been observed between naphthoquinones, dihydrofuranonaphthoquinones and anthraquinones

Key words

T cell polarisation - HuT-78 T lymphocytes - naphthoquinone - plumbagin - dunnione - 7-hydroxydunnione

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