Diabetologie und Stoffwechsel 2020; 15(03): 211-224
DOI: 10.1055/a-0983-7416
CME-Fortbildung

Diabetes und depressive Störungen

Diabetes and depressive disorders
Hanna Kampling
,
Johannes Kruse

Abstract

Depressive disorders are highly prevalent in patients with diabetes. While depressive disorders themselves require therapy, they also contribute negatively to diabetes-related medical, social and psychological outcomes, and therefore need to be addressed. Disease burden is very high for both diabetes and depression, even more so in case of comorbidity. Comorbid depressive symptoms in patients with diabetes are associated with a reduced quality of life and adherence to treatment regimes, impaired coping abilities, as well as increased morbidity and mortality rates, diabetes-related distress, and economic burden.

The interactions between diabetes and depression are bidirectional. Both diseases appear to have a variety of shared bio-psychosocial, as well as biological risk factors. Recent research implies that the interaction between diabetes and depression cannot be understood as a simple cause-effect relationship but might rather be explained by being part of a disturbed homeostasis of biological and psychological circuits.

Regular depression screenings should be applied to identify depressive symptoms in patients with diabetes. To verify positive screening results, treating physicians have a key role in targeting depression by actively asking patients for depressive symptoms within the last 14 days. If symptoms are present, further diagnostics, and the exploration of psychosocial problems are necessary. In case of a depressive disorder, varieties of effective antidepressant treatments (psychotherapy, psychopharmacological medications) are available. Physical activation and diabetes education programs can be offered additionally. The current paper offers insights on epidemiology, symptoms, interactions, diagnostics, treatments as well as the relationship between physician and patient.

Bei vielen Patienten mit Diabetes finden sich depressive Störungen – sie gehen mit einer deutlich reduzierten Lebensqualität, erhöhter Mortalität sowie gesteigerten krankheitsbezogenen Kosten einher. Oftmals stellen sie bedeutsame Behandlungsbarrieren für den Diabetes dar. Dieser Beitrag gibt einen Überblick über Epidemiologie und Symptomatik, Zusammenhänge, Diagnostik, therapeutische Optionen sowie die Bedeutung der Arzt-Patient-Beziehung.



Publication History

Article published online:
19 June 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 
  • Literatur

  • 1 Chireh B, Li M, D’Arcy C. Diabetes increases the risk of depression: A systematic review, meta-analysis and estimates of population attributable fractions based on prospective studies. Prev Med Rep 2019; 14: 100822
  • 2 Wang F, Wang S, Zong QQ. et al. Prevalence of comorbid major depressive disorder in type 2 diabetes: a meta-analysis of comparative and epidemiological studies. Diabet Med 2019; 36: 961-969
  • 3 Holt RIG, Kalra S. A new DAWN: Improving the psychosocial management of diabetes. Indian J Endocrinol Metab 2013; 17: S95-S99
  • 4 Bo A, Pouwer F, Juul L. et al Prevalence and correlates of diabetes distress, perceived stress and depressive symptoms among adults with early-onset type 2 diabetes: cross-sectional survey results from the Danish DD2 study. Diabet Med 2019; DOI: 10.1111/dme.14087. [Epub ahead of print]
  • 5 Perrin NE, Davies MJ, Robertson N. et al. The prevalence of diabetes-specific emotional distress in people with type 2 diabetes: a systematic review and meta-analysis. Diabet Med 2017; 34: 1508-1520
  • 6 Fisher L, Hessler DM, Polonsky WH. et al. Prevalence of depression in type 1 diabetes and the problem of over-diagnosis. Diabet Med J 2016; 33: 1590-1597
  • 7 Moulton CD, Pickup JC, Ismail K. The link between depression and diabetes: the search for shared mechanisms. Lancet Diabetes Endocrinol 2015; 3: 461-471
  • 8 Jelenik T, Dille M, Müller-Lühlhoff S. et al. FGF21 regulates insulin sensitivity following long-term chronic stress. Mol Metab 2018; 16: 126-138
  • 9 Huth C, Thorand B, Baumert J. et al. Job strain as a risk factor for the onset of type 2 diabetes mellitus: findings from the MONICA/KORA Augsburg cohort study. Psychosom Med 2014; 76: 562-568
  • 10 Jiang L, Atasoy S, Johar H. et al Anxiety boosts progression of prediabetes to type 2 diabetes: findings from the prospective Cooperative Health Research in the Region of Augsburg F4 and FF4 studies. Diabet Med 2020; DOI: 10.1111/dme.14232. [Epub ahead of print]
  • 11 Altevers J, Lukaschek K, Baumert J. et al. Poor structural social support is associated with an increased risk of type 2 diabetes mellitus: findings from the MONICA/KORA Augsburg cohort study. Diabet Med 2016; 33: 47-54
  • 12 Johar H, Emeny RT, Bidlingmaier M. et al. Sex-related differences in the association of salivary cortisol levels and type 2 diabetes. Findings from the cross-sectional population based KORA-age study. Psychoneuroendocrinology 2016; 69: 133-141
  • 13 Lukaschek K, Baumert J, Kruse J. et al. Relationship between posttraumatic stress disorder and type 2 diabetes in a population-based cross-sectional study with 2970 participants. J Psychosom Res 2013; 74: 340-345
  • 14 Kampling H, Petrak F, Farin E. et al. Trajectories of depression in adults with newly diagnosed type 1 diabetes: results from the German Multicenter Diabetes Cohort Study. Diabetologia 2017; 60: 60-68
  • 15 Hofmann M, Köhler B, Leichsenring F. et al Depression as a risk factor for mortality in individuals with diabetes: A meta-analysis of prospective studies. PLoS ONE 2013; 8. Im Internet (Stand: 19.05.2020): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836777/
  • 16 Mendes R, Martins S, Fernandes L. Adherence to medication, physical activity and diet in older adults with diabetes: Its association with cognition, anxiety and depression. J Clin Med Res 2019; 11: 583-592
  • 17 Kretchy IA, Koduah A, Ohene-Agyei T. et al. The association between diabetes-related distress and medication adherence in adult patients with type 2 diabetes mellitus: A cross-sectional study. J Diabetes Res 2020; 2020: 4760624
  • 18 Aronson BD, Sittner KJ, Walls ML. The mediating role of diabetes distress and depressive symptoms in type 2 diabetes medication adherence gender differences. Health Educ Behav 2019; DOI: 10.1177/1090198119885416. [Epub ahead of print]
  • 19 Vogelzangs N, Suthers K, Ferrucci L. et al. Hypercortisolemic depression is associated with the metabolic syndrome in late-life. Psychoneuroendocrinology 2007; 32: 151-159
  • 20 Ismail K, Moulton CD, Winkley K. et al. The association of depressive symptoms and diabetes distress with glycaemic control and diabetes complications over 2 years in newly diagnosed type 2 diabetes: a prospective cohort study. Diabetologia 2017; 60: 2092-2102
  • 21 Bieber C, Gschwendtner K, Müller N. et al. Partizipative Entscheidungsfindung (PEF) – Patient und Arzt als Team. Rehabilitation 2017; 56: 198-213
  • 22 Narita Z, Inagawa T, Stickley A. et al. Physical activity for diabetes-related depression: A systematic review and meta-analysis. J Psychiatr Res 2019; 113: 100-107
  • 23 Kulzer B, Albus C, Herpertz S. et al. Psychosoziales und Diabetes. In: Kellerer M, Müller-Wieland D. Hrsg Praxisempfehlungen der Deutschen Diabetes Gesellschaft. Stuttgart: Thieme; 2018: 268-284
  • 24 Cuijpers P, Karyotaki E, Weitz E. et al. The effects of psychotherapies for major depression in adults on remission, recovery and improvement: a meta-analysis. J Affect Disord 2014; 159: 118-126
  • 25 Driessen E, Van HL, Peen J. et al. Cognitive-behavioral versus psychodynamic therapy for major depression: Secondary outcomes of a randomized clinical trial. J Consult Clin Psychol 2017; 85: 653-663
  • 26 Leichsenring F, Steinert C, Ioannidis JPA. Toward a paradigm shift in treatment and research of mental disorders. Psychol Med 2019; 49: 2111-2117
  • 27 Steinert C, Hofmann M, Kruse J. et al. Relapse rates after psychotherapy for depression – stable long-term effects? A meta-analysis. J Affect Disord 2014; 168: 107-118
  • 28 Li C, Xu D, Hu M. et al. A systematic review and meta-analysis of randomized controlled trials of cognitive behavior therapy for patients with diabetes and depression. J Psychosom Res 2017; 95: 44-54
  • 29 Simson U, Nawarotzky U, Friese G. et al. Psychotherapy intervention to reduce depressive symptoms in patients with diabetic foot syndrome. Diabet Med 2007; 25: 206-212
  • 30 Kampling H, Mittag O, Herpertz S. et al. Can trajectories of glycemic control be predicted by depression, anxiety, or diabetes-related distress in a prospective cohort of adults with newly diagnosed type 1 diabetes? Results of a five-year follow-up from the German multicenter diabetes cohort study (GMDC-Study). Diabetes Res Clin Pract 2018; 141: 106-117
  • 31 Roopan S, Larsen ER. Use of antidepressants in patients with depression and comorbid diabetes mellitus: A systematic review. Acta Neuropsychiatr 2017; 29: 127-139
  • 32 Petrak F, Baumeister H, Skinner TC. et al. Depression and diabetes: treatment and health-care delivery. Lancet Diabetes Endocrinol 2015; 3: 472-485
  • 33 Cipriani A, Furukawa TA, Salanti G. et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Focus Am Psychiatr Publ 2018; 16: 420-429
  • 34 Snoek FJ, Bremmer MA, Hermanns N. Constructs of depression and distress in diabetes: time for an appraisal. Lancet Diabetes Endocrinol 2015; 3: 450-460
  • 35 Atlantis E, Fahey P, Foster J. Collaborative care for comorbid depression and diabetes: a systematic review and meta-analysis. BMJ Open 2014; 4: e004706