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Am J Perinatol 2024; 41(09): 1212-1222
DOI: 10.1055/a-1801-3050
Original Article

Outcomes of Moderately Preterm Infants of Insulin-Dependent Diabetic Mothers

Keyaria D. Gray
1   Department of Pediatrics, Duke University, Durham, North Carolina
,
Shampa Saha
2   Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina
,
Ashley N. Battarbee
3   Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama
,
Charles Michael Cotten
1   Department of Pediatrics, Duke University, Durham, North Carolina
,
Nansi S. Boghossian
4   Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina
,
Michele C. Walsh
5   Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio
,
Rachel G. Greenberg 
1   Department of Pediatrics, Duke University, Durham, North Carolina
6   Duke Clinical Research Institute, Durham, North Carolina
,
for the Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research Network › Author Affiliations
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Abstract

Objective Little is known about the hospital outcomes of moderately preterm (MPT; 29 0/7–33 6/7 weeks gestational age) infants born to insulin-dependent diabetic mothers (IDDMs). We evaluated characteristics and outcomes of MPT infants born to IDDMs compared with those without IDDM (non-IDDM).

Study Design Cohort study of infants from 18 centers included in the MPT infant database from 2012 to 2013. We compared characteristics and outcomes of infants born to IDDMs and non-IDDMs.

Results Of 7,036 infants, 527 (7.5%) were born to IDDMs. Infants of IDDMs were larger at birth, more often received continuous positive pressure ventilation in the delivery room, and had higher risk of patent ductus arteriosus (adjusted relative risk or aRR: 1.49, 95% confidence interval [CI]: 1.20–1.85) and continued hospitalization at 40 weeks postmenstrual age (aRR: 1.55, 95% CI: 1.18–2.05).

Conclusion MPT infants of IDDM received more respiratory support and prolonged hospitalizations, providing further evidence of the important neonatal health consequences of maternal diabetes.

Key Points

  • Little data are available on moderate preterm infants of IDDMs.

  • MPT infants of IDDMs need more respiratory support.

  • Longer neonatal intensive care unit stays among MPT infants of IDDMs.

Keywords

moderate preterm - infants - diabetes - insulin

Note

Dr. Cotten receives grant funding from the NIH (5U10 HD040492–16), is a co-investigator for SBIR NICHD, Baebies, Inc. Comprehensive, Near Patient Assessment of Severe Hypoglycemia in Newborns Using Low Blood Volume; Phase II (grant 4R44HD092154–02), and co-inventor for Cryo-Cell International, Inc. (A-013279). Ms. Saha is an employee of RTI, and a recipient of a NICHD Neonatal Research Network Grant. Dr. Walsh receives grant funding from the NICHD.


Supplementary Material



Publication History

Received: 13 August 2021

Accepted: 14 March 2022

Accepted Manuscript online:
17 March 2022

Article published online:
27 May 2022

© 2022. Thieme. All rights reserved.

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