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Z Geburtshilfe Neonatol 2023; 227(04): 281-286
DOI: 10.1055/a-2057-6248
Original Article

Do Delivery Mode and Anesthesia Management Alter Redox Setting in Neonates?

Goran Rakić
1   Department of Emergency Medicine, University of Novi Sad Medical Faculty, Novi Sad, Serbia
2   Department of Anesthesiology, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
,
Dejan Dobrijević
3   Department of Biochemistry, University of Novi Sad Medical Faculty, Novi Sad, Serbia
4   Department of Laboratory Diagnostics, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
,
Anna Uram-Benka
1   Department of Emergency Medicine, University of Novi Sad Medical Faculty, Novi Sad, Serbia
2   Department of Anesthesiology, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
,
Jelena Antić
5   Department of Surgery, University of Novi Sad Medical Faculty, Novi Sad, Serbia
6   Department of Surgery, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
,
Jasminka Uram-Dubovski
7   Obstetrics and Gynecology Clinic, Clinical Center of Vojvodina, Novi Sad, Serbia
,
Ljiljana Andrijević
3   Department of Biochemistry, University of Novi Sad Medical Faculty, Novi Sad, Serbia
,
Biljana Drašković
1   Department of Emergency Medicine, University of Novi Sad Medical Faculty, Novi Sad, Serbia
2   Department of Anesthesiology, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
› Author Affiliations Funding Information Provincial Secretariat for Higher Education and Scientific Research of Vojvodina, Novi Sad, Serbia — 114–451–2892/2011
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Abstract

Objective Fetal-to-neonatal transition is accompanied by oxidative stress. The degree of oxidative damage may depend on several factors, such as delivery type and obstetric anesthesia type. The objective of the study was to determine if the delivery type and obstetric anesthesia type have an impact on oxidative stress levels in newborns.

Material and methods A prospective study included 150 newborns divided into three groups: neonates delivered vaginally, via cesarean section in general anesthesia, and via cesarean section in spinal anesthesia. Levels of pH, PaO2, lactate, glutathione peroxidase, and thiobarbituric acid reactive substance were quantified and compared between groups.

Results Vaginal delivery was followed by the highest lactate and thiobarbituric acid reactive substance levels and lowest pH, PaO2, and glutathione peroxidase levels. Higher values of thiobarbituric acid reactive substance, PaO2, and glutathione peroxidase and lower pH values were noted in neonates delivered in general anesthesia in comparison to neonates delivered in spinal anesthesia.

Conclusions Neonates delivered in general anesthesia were most prone to oxidative stress, while neonates delivered in spinal anesthesia were least affected by reactive oxygen species.

Key words

oxidative stress - thiobarbituric acid reactive substances - glutathione peroxidase - newborn - pregnancy - anesthesia


Publication History

Received: 13 January 2023

Accepted after revision: 06 March 2023

Article published online:
11 April 2023

© 2023. Thieme. All rights reserved.

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  • References

  • 1 Taravati A, Tohidi F. Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia. Taiwan J Obstet Gynecol 2018; 57: 779-790
    CrossrefPubMedGoogle Scholar
  • 2 Katzer D, Mueller A, Welzing L. et al. Antioxidative status and oxidative stress in the fetal circulation at birth: the effects of time of delivery and presence of labor. Early Hum Dev 2015; 91: 119-124
    CrossrefPubMedGoogle Scholar
  • 3 Nejad RK, Goodarzi MT, Shfiee G. et al. Comparison of oxidative stress markers and serum cortisol between normal labor and selective cesarean section born neonates. J Clin Diagn Res 2016; 10: 1-3
    CrossrefPubMedGoogle Scholar
  • 4 Cindrova-Davies T, Yung HW, Johns J. et al. Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol 2007; 171: 1168-1179
    CrossrefPubMedGoogle Scholar
  • 5 Vakilian K, Ranjbar A, Zarganjfard A. et al. On the relation of oxidative stress in delivery mode in pregnant women; a toxicological concern. Toxicol Mech Methods 2009; 19: 94-99
    CrossrefPubMedGoogle Scholar
  • 6 Adekanle DA, Pius Oparinde D, Atiba AS. et al. Effect of different modes of delivery on cord blood oxidative stress markers. Int J Biomed Sci 2013; 9: 249-254
    CrossrefPubMedGoogle Scholar
  • 7 Saphier O, Schneid-Kofman N, Silberstein E. et al. Does mode of delivery affect neonate oxidative stress in parturition? Review of literature. Arch Gynecol Obstet 2013; 287: 403-406
    CrossrefPubMedGoogle Scholar
  • 8 Iddrisu M, Khan ZH. Anesthesia for cesarean delivery: general or regional anesthesia—a systematic review. Ain-Shams J Anesthesiol 2021; 13: 1
    CrossrefPubMedGoogle Scholar
  • 9 Panfoli I, Candiano G, Malova M. et al. Oxidative stress as a primary risk factor for brain damage in preterm newborns. Front Pediatr 2018; 6: 1-6
    CrossrefPubMedGoogle Scholar
  • 10 Peña-Bautista C, Durand T, Vigor C. et al. Non-invasive assessment of oxidative stress in preterm infants. Free Radic Biol Med 2019; 142: 73-81
    CrossrefPubMedGoogle Scholar
  • 11 Gülbayzar S, Arica V, Hatipoğlu S. et al. Malondialdehyde level in the cord blood of newborn infants. Iran J Pediatr 2011; 21: 313-319
    PubMedGoogle Scholar
  • 12 Chiu DTY, Stults FH, Tappel A. Purification and properties of rat lung soluble glutathione peroxidase. Biochim Biophys Acta 1976; 445: 558-566
    CrossrefPubMedGoogle Scholar
  • 13 Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-310
    CrossrefPubMedGoogle Scholar
  • 14 Abdallah MW, Elzayyat NS, Abdelhaq MM. et al. A comparative study of general anesthesia versus combined spinal-epidural anesthesia on the fetus in cesarean section. Egypt J Anaesth 2014; 30: 155-160
    CrossrefPubMedGoogle Scholar
  • 15 Tonni G, Ferrari B, De Felice C. et al. Fetal acid-base and neonatal status after general and neuraxial anesthesia for elective cesarean section. Int J Gynecol Obstet 2007; 97: 143-146
    CrossrefPubMedGoogle Scholar
  • 16 Einikyte R, Snieckuviene V, Ramasauskaite D. et al. The comparison of umbilical cord arterial blood lactate and pH values for predicting short-term neonatal outcomes. Taiwan J Obstet Gynecol 2017; 56: 745-749
    CrossrefPubMedGoogle Scholar
  • 17 Auten RL, Davis JM. Oxygen toxicity and reactive oxygen species: the devil is in the details. Pediatr Res 2009; 66: 121-127
    CrossrefPubMedGoogle Scholar
  • 18 Rakić G, Uram-Benka A, Fabri Galambos I. et al. Relationship between maternal pregestational body mass index and neonatal oxidative stress. Progr Nutr 2022; 23: e2021319
    PubMedGoogle Scholar
  • 19 Yentur EA, Topcu I, Ekici Z. et al. The effect of epidural and general anesthesia on newborn rectal temperature at elective cesarean section. Braz J Med Biol Res 2009; 42: 863-867
    CrossrefPubMedGoogle Scholar
  • 20 Noor N, Islam N, Moin S. et al. Normal delivery induced stress alters glutathione peroxidase and TNF-α in elderly primigravidas mononuclear cells. Indian J Clin Biochem 2008; 23: 227-232
    CrossrefPubMedGoogle Scholar
  • 21 Zakerihamidi M, Latifnejad Roudsari R, Merghati Khoei E. et al. Vaginal delivery vs. cesarean section: A focused ethnographic study of women’s perceptions in the north of Iran. Int J Community Based Nurs Midwifery 2015; 3: 39-50
    PubMedGoogle Scholar