Zeitschrift für Orthomolekulare Medizin 2023; 21(03): 4-10
DOI: 10.1055/a-2149-1972
Wissen

Was bewirken Biofaktoren bei Diabetes und diabetischen Folgeerkrankungen?

Daniela Birkelbach
,
Klaus Kisters
,
Hans Georg Classen

Zusammenfassung

Patienten mit einem Diabetes mellitus oder diabetischen Begleit- und Folgeerkrankungen können neben der Basistherapie aus gesunder Lebensweise und einer optimierten Glukoseeinstellung von einer zielgerichteten Versorgung mit Biofaktoren wie Vitaminen und Mineralstoffen profitieren. Das gilt insb. für Magnesium, Chrom und Zink sowie die Vitamine B1 und B12.



Publication History

Article published online:
11 October 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Gesellschaft für Biofaktoren (GfB). https://www.gf-biofaktoren.de/symposium-2022/
  • 2 Kaur B. et al. Micronutrient status in type 2 diabetes: a review. Adv Food Nutr Res 2014; 71: 55-100
  • 3 Gröber U. et al. Micronutrients in diabetology: complementary medicine update 2014. Med Monatsschr Pharm 2014; 37 (08) 284-292
  • 4 Hansen CS. et al. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. J Diabetes Complications 2017; 31: 202-208
  • 5 Deutsche Diabetes Gesellschaft (DDG) und diabetesDE – Deutsche Diabetes-Hilfe (Hrsg.). Deutscher Gesundheitsbericht Diabetes 2022. Mainz: Verlag Kirchheim https://www.ddg.info/fileadmin/user_upload/Gesundheitsbericht_2022_final.pdf
  • 6 Rosenfeld RM. et al. Dietary Interventions to Treat Type 2 Diabetes in Adults with a Goal of Remission: An Expert Consensus Statement from the American College of Lifestyle Medicine. Am J Lifestyle Med 2022; 16 (39) 342-362
  • 7 Ziegler D. et al. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Res Clin Pract 2022; 186: 109063
  • 8 Gesellschaft für Biofaktoren (GfB). https://www.gf-biofaktoren.de/diagnose/uebersicht-zur-labordiagnostik/
  • 9 Symposium beim Kongress der Deutschen Diabetes Gesellschaft 2023. https://nai-diabetische-neuropathie.de/diabetes-kongress-2023
  • 10 Arzneimittelkommission der deutschen Ärtzeschaft. Information der britischen Arzneimittelbehörde zu Metformin: Verminderte Vitamin-B12-Spiegel – Empfehlungen für die Überwachung von Risikopatienten. Drug Safety Mail 2022-34. https://www.akdae.de/service/newsletter/newsletter-archiv/akdae-news/newsdetail/drug-safety-mail-2022-34
  • 11 Yang W. et al. Associations between metformin use and vitamin B12 level, anemia and neuropathy in patients with diabetes: a meta-analysis. J Diabetes 2019; 11 (09) 729-743
  • 12 Kakarlapudi Y. et al. Effect of Metformin on Vitamin B12 Deficiency in Patients with Type 2 Diabetes Mellitus and Factors Associated with It: A Meta-Analysis. Cureus 2022; 14 (12) e32277
  • 13 Damião CP. et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study. Sao Paulo Med J 2016; 134 (06) 473-479
  • 14 Hansen CS. et al. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. J Diabetes Complications 2017; 31: 202-208
  • 15 Moore E. et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care 2013; 36: 2981-2987
  • 16 Pop-Busui R. et al. Diagnosis and treatment of painful diabetic peripheral neuropathy. Arlington (VA): American Diabetes Association; 2022
  • 17 Gröber U. et al. Magnesium in prevention and therapy. Nutrients 2015; 7 (09) 8199-8226
  • 18 Simental-Mendía LE. et al. A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res 2016; 111: 272-282
  • 19 Veronese N. et al. Magnesium and health outcomes: an umbrella review of systematic reviews and meta-analyses of observational and intervention studies. Eur J Nutr 2020; 59 (01) 263-272
  • 20 Lopez-Ridaura R. et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 2004; 27: 134-140
  • 21 Kisters K: Magnesiummangel in der Praxis: vom Muskelkrampf bis zum metabolischen Syndrom. https://cme.medlearning.de/woerwag/magnesiummangel/index.htm
  • 22 Arpaci D. et al. Associations of serum magnesium levels with diabetes mellitus and diabetic complications. Hippokratia 2015; 19 (02) 153-157
  • 23 Micke O. et al. Magnesium – Bedeutung für die hausärztliche Praxis: Positionspapier der Gesellschaft für Magnesium-Forschung e. V.. Dtsch Med Wochenschr 2020; 145 (22) 1628-1634
  • 24 Cefalu WT. et al. Role of chromium in human health and in diabetes. Diabetes Care 2004; 27 (11) 2741-2751
  • 25 Balk EM. et al. Effect of chromium supplementation on glucose metabolism and lipids. Diabetes Care 2007; 30 (08) 2154-2163
  • 26 Jansen J. et al. Zinc and diabetes – clinical links and molecular mechanisms. J Nutr Biochem 2009; 20: 399-417
  • 27 Wang W. et al. Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2019; 110 (01) 76-90
  • 28 Jayawardena R. et al. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr 2012; 4 (01) 13
  • 29 Momen-Heravi M. et al. The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Wound Rep Reg 2017; 25: 512-520
  • 30 European Commission: Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Zinc (expressed on 5 March 2003). SCF/CS/NUT/UPPLEV/62
  • 31 Andrès E. et al. Systematic review and pragmatic clinical approach to oral and nasal vitamin B12 (Cobalamin) treatment in patients with vitamin B12 deficiency related to gastrointestinal disorders. J Clin Med 2018; 7: 304
  • 32 Ziegler D. et al. Association between diabetes and thiamine status – A systematic review and meta-analysis. Metabolism 2023; 144: 155565
  • 33 Reiners K, Haslbeck M. Sensomotorische diabetische Neuropathien. Diabetologe 2006; 2: 92-103
  • 34 Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Inter J of Clin Pharm and Ther 1996; 34 (02) 47-50
  • 35 Stirban A. Therapie der diabetischen Neuropathie. 27. Kongress der Föderation der Internationalen Donau-Symposia über Diabetes mellitus. Diabetes-Congress-Report 2013; 2: 4-10
  • 36 Raj V. et al. Therapeutic potential of benfotiamine and its molecular targets. Eur Rev Med Pharmacol Sci 2018; 22: 3261-3273