Introduction of Fluorinated Groups via Photoredox-Catalyzed C–H Functionalization of (Hetero-)Arenes

Dedicated to Prof. B. C. Ranu on the occasion of his 75^th birthday

Abstract

In recent years, there have been increasing efforts in the development of methodologies for incorporating fluorine-containing functional groups into organic scaffolds. Modern techniques have made fluorinated molecules more accessible than ever before, but many fluorination reactions still have limitations in their generality, predictability, sustainability, and cost-effectiveness. The methodological progress has a significant impact on drug discovery and materials science research. Photoredox catalysis has enabled the discovery of effective methods, providing access to druglike molecules. Photochemical methods paired with C–H functionalization provide powerful tools for property-driven research. Herein, we examine recent developments at the interface of photoredox catalysis and C–H functionalization.

1 Introduction

2 Fluorinations

3 Fluoroalkylations

4 Fluoroalkoxylations

5 Conclusion

Key words

fluorine - radical reactions - photochemistry - trifluoromethyl - fluoromethoxy

Publication History

Received: 26 June 2024

Accepted after revision: 31 July 2024

Accepted Manuscript online:
31 July 2024

Article published online:
23 August 2024

• References and Notes

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