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Planta Med 1975; 28(5): 1-5
DOI: 10.1055/s-0028-1097822
© Georg Thieme Verlag Stuttgart · New York

ON THE BIOSYNTHESIS OF PILOCARPINE

E. Brochmann–Hanssen, M. A. Nunes, C. K. Olah
  • Department of Pharmaceutical Chemistry, School of Pharmacy, University of California at San Francisco, California 94143, U.S.A.
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Publication Date:
14 January 2009 (online)

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Abstract

[S–Methyl–14C] methionine gave good incorporation into pilocarpine in Pilocarpus pennatifolius when administered by the cut stem method. Controlled degradation showed all radioactivity to reside in the N–methyl group. No significant incorporation was obtained with sodium acetate, threonine or histidine.