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Planta Med 2010; 76(6): 620-625
DOI: 10.1055/s-0029-1240611
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Minor Secondary Metabolic Products from the Stem Bark of Plumeria rubra Linn. Displaying Antimicrobial Activities

Guy Merlin Kuigoua1 , 2 , Simeon F. Kouam1 , 2 , Bonaventure T. Ngadjui3 , Barbara Schulz4 , Ivan R. Green5 , M. Iqbal Choudhary6 , Karsten Krohn1
  • 1Department of Chemistry, University of Paderborn, Paderborn, Germany
  • 2Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, Yaounde, Cameroon
  • 3Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon
  • 4Institute of Microbiology, University of Braunschweig, Braunschweig, Germany
  • 5Department of Chemistry, University of the Western Cape, Bellville, South Africa
  • 6H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Further Information

Publication History

received July 20, 2009 revised October 8, 2009

accepted October 25, 2009

Publication Date:
20 November 2009 (online)

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Abstract

Four new iridoids viz., plumeridoids A (1), B (2), and C (3) and epiplumeridoid C (4) were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-(p-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, p-E-coumaric acid, 2,6-dimethoxy-p-benzoquinone, scopoletin, cycloart-25-en-3β,24-diol, 2,4,6-trimethoxyaniline, ajunolic acid, ursolic acid, oleanolic acid, β-amyrin acetate, betulinic acid, lupeol and its acetate, 2,3-dihydroxypropyl octacosanoate, glucoside of β-sitosterol, and a mixture of common sterols (stigmasterol and β-sitosterol). Their structures were determined by means of spectroscopic data including HREIMS, 1H NMR, 13C NMR, 2D NMR (HMQC, HMBC, NOESY) and by comparison with published data. All but one of thirteen tested compounds exhibited antifungal, antialgal, and/or antibacterial activities.

Key words

Plumeria rubra - Apocynaceae - iridoids - plumeridoids A–C - antimicrobial activity

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Prof. Simeon F. Kouam

Department of Chemistry
Higher Teachers' Training College
University of Yaounde 1

BP 47, Yaounde

Cameroon

Phone: + 2 37 94 46 45 35/22 06 64 46

Email: kfogue@yahoo.com

    www.thieme-connect.de/ejournals/toc/plantamedica
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