Planta Med 2010; 76(13): 1464-1467
DOI: 10.1055/s-0029-1240939
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Two New Phenylpropanoid Derivatives and Other Constituents from Illicium simonsii Active Against Oral Microbial Organisms

Ji-Feng Liu1 , 2 , Zhi-Yong Jiang1 , Chang-An Geng1 , 2 , Xiao-Bin Zou3 , Yao Shi3 , Yun-Bao Ma1 , Xue-Mei Zhang1 , Ji-Jun Chen1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 2Graduate School of Chinese Academy of Sciences, Beijing, P. R. China
  • 3Hawley & Hazel Chemical (ZS) Co., Ltd., Zhongshan, Guangdong, P. R. China
Further Information

Publication History

received December 10, 2009 revised January 29, 2010

accepted February 2, 2010

Publication Date:
01 March 2010 (online)

Abstract

Bioassay-guided fractionation of the ethanol extract of the leaves and stems of Illicium simonsii led to the isolation of two new compounds, simonin A (1) and 1-hydroxyl-2-O-β-D-6′-acetyl-glucopyranosyl-4-allylbenzene (2), along with eight known compounds. Their structures were elucidated by spectroscopic analysis. The isolates were tested for anti-oral microbial activity using a microdilution method. Compounds 1 and 36 showed significant activities against oral microbial organisms (Actinomyces viscosus, Streptococcus mutans, Streptococcus sanguis, and Actinomyces naeslundii), with minimum inhibitory concentration (MIC) values ranging from 1.95 to 31.25 µg/mL in vitro.

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Prof. Dr. Ji-Jun Chen

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

Heilongtan

650204 Kunming

People's Republic of China

Phone: + 86 87 15 22 32 65

Fax: + 86 87 15 22 32 65

Email: chenjj@mail.kib.ac.cn