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DOI: 10.1055/s-0029-1240939
© Georg Thieme Verlag KG Stuttgart · New York
Two New Phenylpropanoid Derivatives and Other Constituents from Illicium simonsii Active Against Oral Microbial Organisms
Publication History
received December 10, 2009
revised January 29, 2010
accepted February 2, 2010
Publication Date:
01 March 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201013/lookinside/thumbnails/10.1055-s-0029-1240939-1.jpg)
Abstract
Bioassay-guided fractionation of the ethanol extract of the leaves and stems of Illicium simonsii led to the isolation of two new compounds, simonin A (1) and 1-hydroxyl-2-O-β-D-6′-acetyl-glucopyranosyl-4-allylbenzene (2), along with eight known compounds. Their structures were elucidated by spectroscopic analysis. The isolates were tested for anti-oral microbial activity using a microdilution method. Compounds 1 and 3–6 showed significant activities against oral microbial organisms (Actinomyces viscosus, Streptococcus mutans, Streptococcus sanguis, and Actinomyces naeslundii), with minimum inhibitory concentration (MIC) values ranging from 1.95 to 31.25 µg/mL in vitro.
Key words
Illiciaceae - Illicium simonsii - neolignans - anti-oral microbial activity
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- Supporting Information .
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Prof. Dr. Ji-Jun Chen
State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences
Heilongtan
650204 Kunming
People's Republic of China
Phone: + 86 87 15 22 32 65
Fax: + 86 87 15 22 32 65
Email: chenjj@mail.kib.ac.cn
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