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Planta Med 2012; 78(16): 1783-1786
DOI: 10.1055/s-0032-1315368
Letters
Georg Thieme Verlag KG Stuttgart · New York

New Phenolic Compounds with Anti-adipogenic Activity from the Aerial Parts of Pulsatilla koreana

Qing Liu
1   College of Pharmacy, Chungbuk National University, Cheongju, Korea
,
Jong Hoon Ahn
1   College of Pharmacy, Chungbuk National University, Cheongju, Korea
,
Seon Beom Kim
1   College of Pharmacy, Chungbuk National University, Cheongju, Korea
,
Bang Yeon Hwang
1   College of Pharmacy, Chungbuk National University, Cheongju, Korea
,
Mi Kyeong Lee
1   College of Pharmacy, Chungbuk National University, Cheongju, Korea
› Author Affiliations
Further Information

Publication History

received 12 April 2012
revised 12 August 2012

accepted 22 August 2012

Publication Date:
24 September 2012 (online)

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Abstract

Three new phenolic compounds, pulsatillosides A (1), B (2), and C (3), were isolated from the aerial parts of Pulsatilla koreana, together with two known flavonoid glycosides, trans-tiliroside (4) and kaempferol-3-O-β-glycoside (5). The structures of the isolated compounds were determined on the basis of spectroscopic analysis including 1D, 2D NMR and HR-MS. Among the isolated compounds, compounds 1–3 significantly inhibited adipocyte differentiation as measured by fat accumulation in 3 T3-L1 cells using Oil Red O staining.

Key words

Pulsatilla koreana - Ranunculaceae - pulsatillosides A–C - adipocyte differentiation

Supporting Information

 

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