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Thromb Haemost 1971; 26(01): 071-076
DOI: 10.1055/s-0038-1653656
Originalarbeiten – Original Articles – Travaux Originaux
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Production of the Generalized Shwartzman Reaction by Activated Hageman Factor and α-Adrenergic Stimulation

D.G McKay M. D
1   Department of Pathology University of California School of Medicine San Francisco General Hospital 1001 Potrero Avenue San Francisco, California 94110 U.S.A
,
J.-G Latour Ph. D
1   Department of Pathology University of California School of Medicine San Francisco General Hospital 1001 Potrero Avenue San Francisco, California 94110 U.S.A
,
Anatalia M. Lopez M. D
1   Department of Pathology University of California School of Medicine San Francisco General Hospital 1001 Potrero Avenue San Francisco, California 94110 U.S.A
› Author AffiliationsThis research was aided by Grant HE-12033-03 from the National Institutes of Health, United States Public Health Service.
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Publication Date:
28 June 2018 (online)

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Summary

Infusion of activated purified Hageman factor and norepinephrine into pregnant rats produces renal glomerular capillary thrombosis identical to the generalized Shwartzman reaction. Activated Hageman factor alone, norepinephrine alone, and inosithin (a substitute for platelet phospholipid) alone, in addition to the combination of inosithin and norepinephrine were incapable of causing the reaction. These studies confirm the evidence that four basic components of the reaction are 1. activation of Hageman factor, 2. platelet phospholipid, 3. ‘‘fibrinolysin inhibition’’, and 4. stimulation of α-adrenergic receptor sites.

Dr. Latour is a Fellow of the Medical Research Council of Canada.


Dr. Lopez is from the North General Hospital, Manila, Philippine Islands.


 

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