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Thromb Haemost 1971; 26(01): 083-087
DOI: 10.1055/s-0038-1653658
Originalarbeiten – Original Articles – Travaux Originaux
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Relationship between Plasma Fibrinolytic Activity and Serum Fibrinogen Degradation Products (FDP) Tested by Various Methods

B Lipiński
1   Department of Biochemistry, Postgraduate Medical School, Warszawa
2   3rd Medical Department, Silesian School of Medicine, Katowice, Poland
,
A Nowak
1   Department of Biochemistry, Postgraduate Medical School, Warszawa
2   3rd Medical Department, Silesian School of Medicine, Katowice, Poland
,
A Odrzywolska
1   Department of Biochemistry, Postgraduate Medical School, Warszawa
2   3rd Medical Department, Silesian School of Medicine, Katowice, Poland
,
J Dosiak
1   Department of Biochemistry, Postgraduate Medical School, Warszawa
2   3rd Medical Department, Silesian School of Medicine, Katowice, Poland
› Author Affiliations
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Publication Date:
28 June 2018 (online)

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Summary

It was found in the present work that the level of serum fibrinogen degradation products (FDP) determined by the immunoassay method correlated well with the staphylococcal clumping titer in serum (correlation coefficient r = 0.68). The content of FDP in serum of 30 healthy subjects and patients with various diseases did not correlate, however, neither with blood fibrinolytic activity estimated by the euglobulin clot lysis time, nor with fibrinogen content and plasma anticlotting activity. It is concluded, that FDP appear in circulation as a result of local proteolytic degradation of intravascularly deposited fibrin without generalized activation of fibrinolysis.

 

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