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Synthesis 2021; 53(08): 1495-1502
DOI: 10.1055/s-0040-1705984
DOI: 10.1055/s-0040-1705984
paper
Synthesis of N-Aryl-4-arylhexahydroquinoline Derivatives by Reaction of Cyclic Enaminones with Arylidenemalononitriles in DMSO
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Abstract
The reaction of cyclic enaminones with arylidenemalononitriles was carried out in the presence of 13X molecular sieves in dimethyl sulfoxide. Under these mild reaction conditions, various bioactive N-aryl-4-arylhexahydroquinoline derivatives were obtained in high yields without the necessity of using transition-metal catalyst, organobase, or reflux conditions.
Key words
dimethyl sulfoxide - molecular sieves - cyclic enaminones - arylidenemalononitriles - N-aryl-4-arylhexahydroquinolinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1705984.
- Supporting Information
Publication History
Received: 23 September 2020
Accepted after revision: 12 November 2020
Article published online:
08 December 2020
© 2020. Thieme. All rights reserved
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For selected examples, see:
For selected examples, see:
For catalyst-free reactions in DMSO reported by our group, see: