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Am J Perinatol 2024; 41(S 01): e827-e832
DOI: 10.1055/s-0042-1758488
Original Article

Ischemic-Modified Albumin in Neonates with Congenital Heart Defects

Didem G. Korkut
1   Departemnt of Pediatrics, Çukurova University Medical Faculty, Adana, Turkey
,
Ferda Özlü 
2   Department of Neonatology, Çukurova University Medical Faculty, Adana, Turkey
,
Gülizar Atlı
3   Department of Biotechnology Centre, Çukurova University Medical Faculty, Adana, Turkey
,
Şule M. Yıldız
3   Department of Biotechnology Centre, Çukurova University Medical Faculty, Adana, Turkey
,
Fadli Demir
4   Department of Pediatric Cardiology, Çukurova University Medical Faculty, Adana, Turkey
,
Uğur Göçen
5   Department of Cardiovascular Surgery, Çukurova University Medical Faculty, Adana, Turkey
,
Hacer Yapıcıoğlu
2   Department of Neonatology, Çukurova University Medical Faculty, Adana, Turkey
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Abstract

Objectives Ischemia-modified albumin (IMA) is a new biochemical marker of ischemia. We aimed to search blood IMA levels in neonates with congenital heart defects.

Study Design During the study period, patients diagnosed with congenital heart disease and newborns with a diagnosis of hyperbilirubinemia as a control group were included in the study. IMA level was analyzed using the IMA absorbance unit (ABSU) method.

Results In total, 57 newborns with congenital heart disease requiring cardiac operation for the study group and 38 newborns for the control group were included. There was no difference between the two groups in terms of gender, mode of delivery, and weeks of gestation. The average IMA values in the control group were 0.19 ± 0.09 ABSU. The prepostoperative mean IMA values of the patient group were 0.22 ± 0.07 and 0.23 ± 0.07 ABSU, respectively. Comparison of the postoperative IMA with the mean of the control group was statistically significant. Preoperative and postoperative IMA values of patients who have died due to primary heart disease and surgical complications were 0.21 ± 0.07 (0.08–0.32) ABSU and 0.25 ± 0.06 (0.12–0.36) ABSU, respectively. IMA levels were not statistically different between the two groups.

Conclusion Hypoxia and ischemia in congenital heart disease in the newborn period both preoperatively and postoperatively were important in prognosis. IMA was higher in the postoperative group. Many comprehensive studies are important in terms of preventing complications and decreasing mortality and morbidity by commenting on prognosis.

Key Points

  • IMA is a new biochemical marker of ischemia.

  • In the literature, there are no reports about the relation between congenital heart defects and IM.

  • The exposure of CHD patients to hypoxia/asphyxia in the preintra and postoperative periods cause neurologic deficits

Keywords

ischemia-modified albumin - newborn - congenital heart disease - ischemia


Publication History

Received: 05 May 2022

Accepted: 12 September 2022

Article published online:
30 December 2022

© 2022. Thieme. All rights reserved.

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