Am J Perinatol 2024; 41(S 01): e2907-e2918
DOI: 10.1055/s-0043-1776345
Original Article

Impact of Race/Ethnicity and Insurance Status on Obstetric Outcomes: Secondary Analysis of the NuMoM2b Study

Maria S. Rayas
1   Department of Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, Texas
,
Jessian L. Munoz
2   Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, San Antonio, Texas
,
2   Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, San Antonio, Texas
,
Jennifer Kim
1   Department of Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, Texas
,
Cheyenne Mangold
1   Department of Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, Texas
,
Alvaro Moreira
1   Department of Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, Texas
› Author Affiliations
Funding This work was supported by Parker B. Francis (A.M.); Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health K23HD101701 (A.M.), National Center for Advancing Translational Sciences, National Institute of Health Grant KL2 TR002646 (M.S.R.), and the Cystic Fibrosis Foundation (M.S.R.).

Abstract

Objective This study aimed to investigate the impact of race/ethnicity and insurance status on obstetric outcomes in nulliparous women.

Study Design Secondary analysis of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-To-Be. Obstetric outcomes included the development of a hypertensive event during pregnancy, need for a cesarean section, delivery of a preterm neonate, and postpartum hemorrhage.

Results Of 7,887 nulliparous women, 64.7% were non-Hispanic White (White), 13.4% non-Hispanic Black (Black), 17.8% Hispanic, and 4.1% were Asian. Black women had the highest rates of developing new-onset hypertension (32%) and delivering preterm (11%). Cesarean deliveries were the highest in Asian (32%) and Black women (32%). Individuals with government insurance were more likely to deliver preterm (11%) and/or experience hemorrhage after delivery. In multivariable analyses, race/ethnicity was associated with hypertension and cesarean delivery. More important, the adjusted odds ratios for preventable risk factors, such as obesity, diabetes, and severe anemia were greater than the adjusted odds ratios for race/ethnicity in terms of poor maternal outcome.

Conclusion Although disparities were observed between race/ethnicity and obstetric outcomes, other modifiable risk factors played a larger role in clinical differences.

Key Points

  • Race or insurance alone had mixed associations with maternal morbidities.

  • Race and insurance had low associations with maternal morbidities.

  • Other, modifiable risk factors may be more important.

  • Both social and biological factors impact health disparities.

Authors' Contributions

M.S.R.: manuscript writing, interpretation of findings; J.L.M.: study design, review of manuscript; A.B.: study design, review of manuscript; C.M.: data analytics, review of manuscript; J.K.: manuscript writing; A.M.: study design, data analytics, manuscript writing, oversight.


Data Availability Statement

Data are publicly accessible to researchers upon request via the National Institutes of Health Data and Specimen Hub Web site: https://dash.nichd.nih.gov/. The corresponding author (A.M.) should be contacted if someone has questions regarding the study or if they want some assistance on how to request data from the National Institutes of Health Data and Specimen Hub.




Publication History

Received: 14 December 2022

Accepted: 26 September 2023

Article published online:
07 November 2023

© 2023. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Riley WJ. Health disparities: gaps in access, quality and affordability of medical care. Trans Am Clin Climatol Assoc 2012; 123: 167-172 , discussion 172–174
  • 2 GBD US Health Disparities Collaborators. . Life expectancy by county, race, and ethnicity in the USA, 2000-19: a systematic analysis of health disparities. 2022;400(10345):25–38
  • 3 Fryer K, Munoz MC, Rahangdale L, Stuebe AM. Multiparous Black and Latinx women face more barriers to prenatal care than white women. J Racial Ethn Health Disparities 2021; 8 (01) 80-87
  • 4 Lee H, Okunev I, Tranby E, Monopoli M. Different levels of associations between medical co-morbidities and preterm birth outcomes among racial/ethnic women enrolled in Medicaid 2014-2015: retrospective analysis. BMC Pregnancy Childbirth 2020; 20 (01) 33
  • 5 Bailey ZD, Krieger N, Agénor M, Graves J, Linos N, Bassett MT. Structural racism and health inequities in the USA: evidence and interventions. Lancet 2017; 389 (10077): 1453-1463
  • 6 Bryant AS, Worjoloh A, Caughey AB, Washington AE. Racial/ethnic disparities in obstetric outcomes and care: prevalence and determinants. Am J Obstet Gynecol 2010; 202 (04) 335-343
  • 7 Willinger M, Ko CW, Reddy UM. Racial disparities in stillbirth risk across gestation in the United States. Am J Obstet Gynecol 2009; 201 (05) 469.e1-469.e8
  • 8 Tucker MJ, Berg CJ, Callaghan WM, Hsia J. The Black-White disparity in pregnancy-related mortality from 5 conditions: differences in prevalence and case-fatality rates. Am J Public Health 2007; 97 (02) 247-251
  • 9 Rosenberg D, Geller SE, Studee L, Cox SM. Disparities in mortality among high risk pregnant women in Illinois: a population based study. Ann Epidemiol 2006; 16 (01) 26-32
  • 10 Guendelman S, Thornton D, Gould J, Hosang N. Obstetric complications during labor and delivery: assessing ethnic differences in California. Womens Health Issues 2006; 16 (04) 189-197
  • 11 Goldberg J, Hyslop T, Tolosa JE, Sultana C. Racial differences in severe perineal lacerations after vaginal delivery. Am J Obstet Gynecol 2003; 188 (04) 1063-1067
  • 12 Combs CA, Murphy EL, Laros Jr RKJ. Factors associated with postpartum hemorrhage with vaginal birth. Obstet Gynecol 1991; 77 (01) 69-76
  • 13 Bryant A, Mhyre JM, Leffert LR, Hoban RA, Yakoob MY, Bateman BT. The association of maternal race and ethnicity and the risk of postpartum hemorrhage. Anesth Analg 2012; 115 (05) 1127-1136
  • 14 Grobman WA, Bailit JL, Rice MM. et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Racial and ethnic disparities in maternal morbidity and obstetric care. Obstet Gynecol 2015; 125 (06) 1460-1467
  • 15 Gadson A, Akpovi E, Mehta PK. Exploring the social determinants of racial/ethnic disparities in prenatal care utilization and maternal outcome. Semin Perinatol 2017; 41 (05) 308-317
  • 16 Sastow DL, Jiang SY, Tangel VE. et al. Patient race and racial composition of delivery unit associated with disparities in severe maternal morbidity: a multistate analysis 2007-2014. Int J Obstet Anesth 2021; 47: 103160
  • 17 Tangel VE, Matthews KC, Abramovitz SE, White RS. Racial and ethnic disparities in severe maternal morbidity and anesthetic techniques for obstetric deliveries: a multi-state analysis, 2007-2014. J Clin Anesth 2020; 65: 109821
  • 18 McQuistion K, Zens T, Jung HS. et al. Insurance status and race affect treatment and outcome of traumatic brain injury. J Surg Res 2016; 205 (02) 261-271
  • 19 Englum BR, Hui X, Zogg CK. et al. Association between insurance status and hospital length of stay following trauma. Am Surg 2016; 82 (03) 281-288
  • 20 Short SS, Liou DZ, Singer MB. et al. Insurance type, not race, predicts mortality after pediatric trauma. J Surg Res 2013; 184 (01) 383-387
  • 21 Mikhail JN, Nemeth LS, Mueller M. et al. The association of race, socioeconomic status, and insurance on trauma mortality. J Trauma Nurs 2016; 23 (06) 347-356
  • 22 Hagerty V, Samuels S, Levene T, Patel D, Levene H, Spader H. Inpatient hospital outcomes and its association with insurance type among pediatric neurosurgery trauma patients. World Neurosurg 2020; 141: e484-e489
  • 23 Haas DM, Parker CB, Wing DA. et al; NuMoM2b Study. A description of the methods of the Nulliparous Pregnancy Outcomes study: monitoring mothers-to-be (nuMoM2b). Am J Obstet Gynecol 2015; 212 (04) 539.e1-539.e24
  • 24 ACOG Committee on Obstetric Practice, American College of Obstetricians and Gynecologists. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Int J Gynaecol Obstet 2002; 77 (01) 67-75
  • 25 Marcoulides KM, Raykov T. Evaluation of variance inflation factors in regression models using latent variable modeling methods. Educ Psychol Meas 2019; 79 (05) 874-882
  • 26 R Core Team. R: a language and environment for statistical computing. 2021 https://www.r-project.org/
  • 27 Delisle Nyström C, Barnes JD, Tremblay MS. An exploratory analysis of missing data from the Royal Bank of Canada (RBC) Learn to Play - Canadian Assessment of Physical Literacy (CAPL) project. BMC Public Health 2018; 18 (Suppl. 02) 1046
  • 28 Grobman WA, Parker CB, Willinger M. et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) Network*. Racial disparities in adverse pregnancy outcomes and psychosocial stress. Obstet Gynecol 2018; 131 (02) 328-335
  • 29 Ghosh G, Grewal J, Männistö T. et al. Racial/ethnic differences in pregnancy-related hypertensive disease in nulliparous women. Ethn Dis 2014; 24 (03) 283-289
  • 30 Edmonds JK, Yehezkel R, Liao X, Moore Simas TA. Racial and ethnic differences in primary, unscheduled cesarean deliveries among low-risk primiparous women at an academic medical center: a retrospective cohort study. BMC Pregnancy Childbirth 2013; 13: 168
  • 31 Okwandu IC, Anderson M, Postlethwaite D, Shirazi A, Torrente S. Racial and ethnic disparities in cesarean delivery and indications among nulliparous, term, singleton, vertex women. J Racial Ethn Health Disparities 2022; 9 (04) 1161-1171
  • 32 Washington S, Caughey AB, Cheng YW, Bryant AS. Racial and ethnic differences in indication for primary cesarean delivery at term: experience at one U.S. Institution. Birth 2012; 39 (02) 128-134
  • 33 Hedderson MM, Xu F, Liu E, Sridhar SB, Quesenberry CP, Flanagan TA. Mediating effects of cardiometabolic risk factors on the association between maternal race-ethnicity and cesarean delivery among low-risk women. J Womens Health (Larchmt) 2021; 30 (07) 1028-1037
  • 34 Gyamfi-Bannerman C, Srinivas SK, Wright JD. et al. Postpartum hemorrhage outcomes and race. Am J Obstet Gynecol 2018; 219 (02) 185.e1-185.e10
  • 35 Erickson EN, Lee CS, Carlson NS. Predicting postpartum hemorrhage after vaginal birth by labor phenotype. J Midwifery Womens Health 2020; 65 (05) 609-620
  • 36 Fingar KR, Hambrick MM, Heslin KC, Moore JE. Trends and Disparities in Delivery Hospitalizations Involving Severe Maternal Morbidity, 2006–2015. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); September 4, 2018
  • 37 Creanga AA, Bateman BT, Kuklina EV, Callaghan WM. Racial and ethnic disparities in severe maternal morbidity: a multistate analysis, 2008-2010. Am J Obstet Gynecol 2014; 210 (05) 435.e1-435.e8
  • 38 Greiner KS, Speranza RJ, Rincón M, Beeraka SS, Burwick RM. Association between insurance type and pregnancy outcomes in women diagnosed with hypertensive disorders of pregnancy. J Matern Fetal Neonatal Med 2020; 33 (08) 1427-1433
  • 39 Taylor YJ, Liu TL, Howell EA. Insurance differences in preventive care use and adverse birth outcomes among pregnant women in a Medicaid nonexpansion state: a retrospective cohort study. J Womens Health (Larchmt) 2020; 29 (01) 29-37
  • 40 Yogev Y, Catalano PM. Pregnancy and obesity. Obstet Gynecol Clin North Am 2009; 36 (02) 285-300 , viii
  • 41 Linné Y. Effects of obesity on women's reproduction and complications during pregnancy. Obes Rev 2004; 5 (03) 137-143
  • 42 Spradley FT, Palei AC, Granger JP. Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms. Am J Physiol Regul Integr Comp Physiol 2015; 309 (11) R1326-R1343
  • 43 Spradley FT. Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia. Am J Physiol Regul Integr Comp Physiol 2017; 312 (01) R5-R12
  • 44 Wispelwey BP, Sheiner E. Cesarean delivery in obese women: a comprehensive review. J Matern Fetal Neonatal Med 2013; 26 (06) 547-551
  • 45 Hanson C, Samson K, Anderson-Berry AL, Slotkowski RA, Su D. Racial disparities in caesarean delivery among nulliparous women that delivered at term: cross-sectional decomposition analysis of Nebraska birth records from 2005-2014. BMC Pregnancy Childbirth 2022; 22 (01) 329
  • 46 Beigelman A, Wiznitzer A, Shoham-Vardi I, Vardi H, Holtcberg G, Mazor M. [Premature delivery in diabetes: etiology and risk factors]. Harefuah 2000; 138 (11) 919-923 , 1008, 1007
  • 47 Kayemba-Kay's S, Peters C, Geary MPP, Hill NR, Mathews DR, Hindmarsh PC. Maternal hyperinsulinism and glycaemic status in the first trimester of pregnancy are associated with the development of pregnancy-induced hypertension and gestational diabetes. Eur J Endocrinol 2013; 168 (03) 413-418
  • 48 Hauth JC, Clifton RG, Roberts JM. et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Maternal insulin resistance and preeclampsia. Am J Obstet Gynecol 2011; 204 (04) 327.e1-327.e6
  • 49 Waters TP, Dyer AR, Scholtens DM. et al; HAPO Cooperative Study Research Group. Maternal and neonatal morbidity for women who would be added to the diagnosis of GDM Using IADPSG criteria: a secondary analysis of the hyperglycemia and adverse pregnancy outcome study. Diabetes Care 2016; 39 (12) 2204-2210
  • 50 Phaloprakarn C, Tangjitgamol S. Risk score for predicting primary cesarean delivery in women with gestational diabetes mellitus. BMC Pregnancy Childbirth 2020; 20 (01) 607
  • 51 Ye W, Luo C, Huang J, Li C, Liu Z, Liu F. Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 2022; 377: e067946
  • 52 Ramsay JE, Ferrell WR, Crawford L, Wallace AM, Greer IA, Sattar N. Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab 2002; 87 (09) 4231-4237
  • 53 Beckert RH, Baer RJ, Anderson JG, Jelliffe-Pawlowski LL, Rogers EE. Maternal anemia and pregnancy outcomes: a population-based study. J Perinatol 2019; 39 (07) 911-919
  • 54 Shi H, Chen L, Wang Y. et al. Severity of anemia during pregnancy and adverse maternal and fetal outcomes. JAMA Netw Open 2022; 5 (02) e2147046
  • 55 Peace JM, Banayan JM. Anemia in pregnancy: pathophysiology, diagnosis, and treatment. Int Anesthesiol Clin 2021; 59 (03) 15-21
  • 56 Chen C, Grewal J, Betran AP, Vogel JP, Souza JP, Zhang J. Severe anemia, sickle cell disease, and thalassemia as risk factors for hypertensive disorders in pregnancy in developing countries. Pregnancy Hypertens 2018; 13: 141-147
  • 57 McAllister-Sistilli CG, Caggiula AR, Knopf S, Rose CA, Miller AL, Donny EC. The effects of nicotine on the immune system. Psychoneuroendocrinology 1998; 23 (02) 175-187
  • 58 Kramer MS, Goulet L, Lydon J. et al. Socio-economic disparities in preterm birth: causal pathways and mechanisms. Paediatr Perinat Epidemiol 2001; 15 (Suppl. 02) 104-123
  • 59 Kyrklund-Blomberg NB, Granath F, Cnattingius S. Maternal smoking and causes of very preterm birth. Acta Obstet Gynecol Scand 2005; 84 (06) 572-577
  • 60 Rosenberg D, Handler A, Rankin KM, Zimbeck M, Adams EK. Prenatal care initiation among very low-income women in the aftermath of welfare reform: does pre-pregnancy Medicaid coverage make a difference?. Matern Child Health J 2007; 11 (01) 11-17