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Synthesis 1986; 1986(2): 142-144
DOI: 10.1055/s-1986-31502
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Synthesis of Furo[3,4-d]pyrimidine Derivatives via Reaction of 4-Methylpyrimidine-5-carboxylic Acids with Thionyl Chloride

Z. Machon* , J. Cieplik
  • *Department of Organic Chemistry, Medical Academy, Wrocław, Poland
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Publication Date:
20 August 2002 (online)

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6-Anilino-5-carboxy-4-methyl-2-phenylpyrimidines undergo an unusual reaction with thionyl chloride to give 4-anilino-5-oxo-2-phenyl-7-thioxo-5, 7-dihydrofuro[3,4-d]pyrimidines, presumably via a sulfine as intermediate.