Synthesis 1986; 1986(7): 582-584
DOI: 10.1055/s-1986-31715
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Preparation of Chiral ß-Hydroxyketones by Aldol-type Condensation of Chiral p-Tolylsulfinylmethyl Ketones

Fernand Schneider* , Roland Simon
  • *Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. AG, CH-4002 Basel, Switzerland
Further Information

Publication History

Publication Date:
20 August 2002 (online)

Chiral ß-hydroxyketones 7 with fair e.e. were prepared by treating newly prepared optically pure p-tolylsulfinylmethyl ketones 4 with t-butyl-magnesium bromide and aldehydes 5 followed by desulfurization with aluminium amalgam.