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Synthesis 1987; 1987(8): 724-726
DOI: 10.1055/s-1987-28062
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A Convenient One-Pot Synthesis of 2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones

Valeria Ambrogi* , Giuliano Grandolini
  • *Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università di Perugia, Via del Liceo, I-06100, Perugia, Italy
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Publication Date:
12 September 2002 (online)

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An improved one-pot synthesis of 1,5-benzothiazepinone derivatives is described. 2-Aminobenzenethiols are conveniently converted into 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones by reaction with ß-propiol-actone or ß-butyrolactone in anhydrous pyridine followed by treatment with acetic anhydride. Some substituent effects are noted.