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Synlett 1992; 1992(2): 153-155
DOI: 10.1055/s-1992-21299
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Synthesis of 2,4-Disubstituted Oxazoles

Fumiaki Yokokawa* , Yasumasa Hamada, Takayuki Shioiri
  • *Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467, Japan
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Publication History

Publication Date:
08 March 2002 (online)

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Some 2-substituted methyl 1,3-oxazole-4-carboxylates (5) can be obtained by the one-step cyclization of N-acylserines (3) by the combined use of diphenyl sulfoxide and trifluoroacetic anhydride, and subsequent nickel peroxide oxidation of the oxazoline.

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