Download PDF
Synlett 1993; 1993(1): 63-64
DOI: 10.1055/s-1993-22350
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Enantioselective Synthesis of (R)-(-)-Baclofen

Angèle Schoenfelder* , André Mann, Sylvie Le Coz
  • *Laboratoire de Pharmacochimie Moléculaire, Centre de Neurochimie, 5, rue Blaise Pascal, F-67084 Strasbourg Cedex, France
Further Information

Publication History

Publication Date:
19 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

An enantioselective synthesis of (R)-baclofen is presented. The chiral imide 2 was alkylated via its imide enolate with ten-butyl bromoacetate. Removal of the chiral auxiliary provided the lactone 5 and further transformations the lactam 8, which could be transformed in (R)-baclofen.

      >