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Synthesis 1995; 1995(4): 431-434
DOI: 10.1055/s-1995-3927
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A New Synthetic Route to Isoquinolin-1(2H)-one Derivatives from 3-Hydroxyphthalides

Akiko Sugimoto* , Hisako Shinba-Tanaka, Masayuki Ishikawa
  • *Department of Medicinal Chemistry, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan, Fax +81(3)52808005; E-mail akiko-s@tansei.cc.u-tokyo.ac.jp
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Publication Date:
31 December 2000 (online)

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A new synthetic route for the conversion of substituted 3-hydroxyphthalides into the corresponding isoquinolin-1(2H)-one was established. This method can be applied to the preparation of isoquinolin-1(2H)-ones with electron-withdrawing groups that are relatively difficult to synthesize by conventional procedures.

A convenient synthesis of isoquinolones from 3-hydroxyphthalides is reported.