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Synlett 1996; 1996(6): 507-508
DOI: 10.1055/s-1996-5476
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A Simple One-Pot Preparation of N,N’-Unsymmetrical Ureas from N-Boc Protected Primary Anilines and Amines

Marie Lamothe* , Michel Perez, Véronique Colovray-Gotteland, Serge Halazy
  • *Medicinal Chemistry Division, Centre de Recherche Pierre Fabre, 17 Avenue Jean Moulin, 81106 Castres Cédex France
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Publication History

Publication Date:
31 December 2000 (online)

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N-Boc protected primary amines and anilines can be converted efficiently into N,N’-unsymmetrically substituted ureas by sequential deprotonation and condensation with amines at 65°C.

amine - aniline - carbamate - unsymmetrical urea