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Synlett 1997; 1997(7): 773-774
DOI: 10.1055/s-1997-5778
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Synthesis of Hydroxyalkyl Isothiocyanates

Hirokuni Tajima* , Ge Li
  • *Fukui Research Laboratory, RENGO Co., Ltd., 10-8-1, Jiyugaoka, Kanazu-cho, Sakai-gun, Fukui 919-06, Japan, Fax +81(776)737041; E-mail taji@mxb.meshnet.or.jp
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Publication History

Publication Date:
31 December 2000 (online)

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Hydroxyalkyl isothiocyanates are prepared in high yields by treating aqueous hydrogen peroxide with a mixture of the corresponding hydroxy primary amine, carbon disulfide, and a catalytic amount of triethylamine, in a water-miscible organic solvent at 0~10 °C.

hydroxyalkyl isothiocyanate - hydrogen peroxide - water-miscible solvent - dithiocarbamate - carbon disulfide