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Planta Med 2002; 68(12): 1131-1133
DOI: 10.1055/s-2002-36358
Letter
© Georg Thieme Verlag Stuttgart · New York

Quinolone Alkaloids, Diacylglycerol Acyltransferase Inhibitors from the Fruits of Evodia rutaecarpa

Jeong Suk Ko1 , Mun-Chual Rho1 , Mi Yeon Chung1 , Hye Young Song1 , Jong Seong Kang2 , Koanhoi Kim1 , Hyun Sun Lee1 , Young Kook Kim1
  • 1Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea
  • 2College of Pharmacy, Chungnam National University, Taejon, Korea
Further Information

Publication History

Received: April 18, 2002

Accepted: September 7, 2002

Publication Date:
20 December 2002 (online)

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Abstract

From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4Z,7Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC50 values of 69.5 μM (1), 23.8 μM (2), 20.1 μM (3) and 13.5 μ (4) .

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Hyun Sun Lee Ph. D.

Laboratory of Lipid Metabolism

Korea Research Institute of Bioscience and Biotechnology

P. O. Box 115, Yusong

Taejon 305-600

Korea

Email: leehs@kribb.re.kr

Phone: +82-42-860-4314

Fax: +82-42-861-2675

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